Plasma levels of the lymphangiogenic factors VEGF-C, VEGF-D, and CXCL-12 are elevated in advanced diabetic nephropathy
Objective Early biomarkers for diabetic nephropathy progression remain limited. This study aims to investigate whether plasma levels of VEGF-C, VEGF-D, and CXCL-12 can reflect the severity of diabetic kidney disease (DKD), and to evaluate their potential as biomarkers for disease monitoring.Methods...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2536196 |
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| _version_ | 1849335747125968896 |
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| author | Qingshan Tian Fan Zhang Zhichao Yang Ji Miao Hao Wu Zhenzhong Zheng |
| author_facet | Qingshan Tian Fan Zhang Zhichao Yang Ji Miao Hao Wu Zhenzhong Zheng |
| author_sort | Qingshan Tian |
| collection | DOAJ |
| description | Objective Early biomarkers for diabetic nephropathy progression remain limited. This study aims to investigate whether plasma levels of VEGF-C, VEGF-D, and CXCL-12 can reflect the severity of diabetic kidney disease (DKD), and to evaluate their potential as biomarkers for disease monitoring.Methods Patients were divided into normal albuminuria group (UmAlb < 30 mg/24 h, n = 30), microalbuminuria group (UmAlb 30–300 mg/24 h, n = 30) and macroalbuminuria group (UmAlb >300 mg/24 h, n = 30). Healthy individuals were included as control group (n = 30). Plasma levels of vascular endothelial growth factor-C (VEGF-C), vascular endothelial growth factor-D (VEGF-D), and chemokine ligand 12 (CXCL-12) were measured.Results The plasma levels of VEGF-C, VEGF-D, and CXCL-12 were significantly increased in all type 2 diabetic kidney disease groups. Correlation analysis revealed that plasma VEGF-C, VEGF-D and CXCL-12 levels were positively correlated with plasma creatinine and urinary microalbumin. Furthermore, these levels were inversely correlated with estimated glomerular filtration rate. In order to distinguish DKD patients in the normal albuminuria group, microalbuminuria group, and macroalbuminuria group, the areas under the receiver operating characteristic curve (AUC-ROCs) of VEGF-C was 0.668 (95%CI: 0.531–0.805), 0.790 (95%CI: 0.678–0.901), and 0.850 (95%CI: 0.756–0.944), respectively. For VEGF-D, the AUC-ROCs were 0.718 (95%CI: 0.587–0.848), 0.873 (95%CI: 0.783–0.963), and 0.931 (95%CI: 0.872–0.991), respectively. Finally, for CXCL-12, the AUC-ROCs were 0.687 (95%CI: 0.554–0.820), 0.816 (95%CI: 0.710–0.921), and 0.903 (95%CI: 0.829–0.977), respectively.Conclusion Plasma VEGF-C, VEGF-D, and CXCL-12 levels is of great value for early diagnosis and assessment of diabetic kidney disease severity. This suggests that these may serve as valuable surrogate markers for clinical outcomes in DKD. |
| format | Article |
| id | doaj-art-1ffd03afd2f441e9bb9612bd7975198c |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-1ffd03afd2f441e9bb9612bd7975198c2025-08-20T03:45:11ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2536196Plasma levels of the lymphangiogenic factors VEGF-C, VEGF-D, and CXCL-12 are elevated in advanced diabetic nephropathyQingshan Tian0Fan Zhang1Zhichao Yang2Ji Miao3Hao Wu4Zhenzhong Zheng5Department of Cardiology, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Nephrology, Haidian Hospital (Haidian section of Peking University Third Hospital), Beijing, ChinaDepartment of Cardiology, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDivision of Endocinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USAVascular Biology Program, Boston Children’s Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USADepartment of Cardiology, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaObjective Early biomarkers for diabetic nephropathy progression remain limited. This study aims to investigate whether plasma levels of VEGF-C, VEGF-D, and CXCL-12 can reflect the severity of diabetic kidney disease (DKD), and to evaluate their potential as biomarkers for disease monitoring.Methods Patients were divided into normal albuminuria group (UmAlb < 30 mg/24 h, n = 30), microalbuminuria group (UmAlb 30–300 mg/24 h, n = 30) and macroalbuminuria group (UmAlb >300 mg/24 h, n = 30). Healthy individuals were included as control group (n = 30). Plasma levels of vascular endothelial growth factor-C (VEGF-C), vascular endothelial growth factor-D (VEGF-D), and chemokine ligand 12 (CXCL-12) were measured.Results The plasma levels of VEGF-C, VEGF-D, and CXCL-12 were significantly increased in all type 2 diabetic kidney disease groups. Correlation analysis revealed that plasma VEGF-C, VEGF-D and CXCL-12 levels were positively correlated with plasma creatinine and urinary microalbumin. Furthermore, these levels were inversely correlated with estimated glomerular filtration rate. In order to distinguish DKD patients in the normal albuminuria group, microalbuminuria group, and macroalbuminuria group, the areas under the receiver operating characteristic curve (AUC-ROCs) of VEGF-C was 0.668 (95%CI: 0.531–0.805), 0.790 (95%CI: 0.678–0.901), and 0.850 (95%CI: 0.756–0.944), respectively. For VEGF-D, the AUC-ROCs were 0.718 (95%CI: 0.587–0.848), 0.873 (95%CI: 0.783–0.963), and 0.931 (95%CI: 0.872–0.991), respectively. Finally, for CXCL-12, the AUC-ROCs were 0.687 (95%CI: 0.554–0.820), 0.816 (95%CI: 0.710–0.921), and 0.903 (95%CI: 0.829–0.977), respectively.Conclusion Plasma VEGF-C, VEGF-D, and CXCL-12 levels is of great value for early diagnosis and assessment of diabetic kidney disease severity. This suggests that these may serve as valuable surrogate markers for clinical outcomes in DKD.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2536196Type 2 diabetic kidney diseaseVEGF-cVEGF-dCXCL-12 |
| spellingShingle | Qingshan Tian Fan Zhang Zhichao Yang Ji Miao Hao Wu Zhenzhong Zheng Plasma levels of the lymphangiogenic factors VEGF-C, VEGF-D, and CXCL-12 are elevated in advanced diabetic nephropathy Renal Failure Type 2 diabetic kidney disease VEGF-c VEGF-d CXCL-12 |
| title | Plasma levels of the lymphangiogenic factors VEGF-C, VEGF-D, and CXCL-12 are elevated in advanced diabetic nephropathy |
| title_full | Plasma levels of the lymphangiogenic factors VEGF-C, VEGF-D, and CXCL-12 are elevated in advanced diabetic nephropathy |
| title_fullStr | Plasma levels of the lymphangiogenic factors VEGF-C, VEGF-D, and CXCL-12 are elevated in advanced diabetic nephropathy |
| title_full_unstemmed | Plasma levels of the lymphangiogenic factors VEGF-C, VEGF-D, and CXCL-12 are elevated in advanced diabetic nephropathy |
| title_short | Plasma levels of the lymphangiogenic factors VEGF-C, VEGF-D, and CXCL-12 are elevated in advanced diabetic nephropathy |
| title_sort | plasma levels of the lymphangiogenic factors vegf c vegf d and cxcl 12 are elevated in advanced diabetic nephropathy |
| topic | Type 2 diabetic kidney disease VEGF-c VEGF-d CXCL-12 |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2536196 |
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