Synthesis, Characterization, and In Vitro Cytotoxicity of Platinum(II) Complexes Bearing Chiral Tetradentate Salicylaldimine Ligands
A series of platinum(II) complexes with chiral Schiff base ligands derived from various salicylaldehydes with (R,R′)- and (S,S′)-cyclohexanediamine were synthesized and characterized by ESI-MS, IR, and NMR. Obtained spectra with typical signals were in agreement with suggested molecular formulae of...
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| Format: | Article |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/5414959 |
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| author | Quang Trung Nguyen Phuong Nam Pham Thi Van Tuyen Nguyen |
| author_facet | Quang Trung Nguyen Phuong Nam Pham Thi Van Tuyen Nguyen |
| author_sort | Quang Trung Nguyen |
| collection | DOAJ |
| description | A series of platinum(II) complexes with chiral Schiff base ligands derived from various salicylaldehydes with (R,R′)- and (S,S′)-cyclohexanediamine were synthesized and characterized by ESI-MS, IR, and NMR. Obtained spectra with typical signals were in agreement with suggested molecular formulae of the complexes. Their photophysical properties were studied by UV-visible and emission spectroscopies. The UV-Vis showed the typical band with low energy at visible range 400–500 nm for MLCT, and this band can emit the luminescent band with emission maximum wavelengths at 529–595 nm. The in vitro cytotoxicity of obtained platinum(II) complexes was screened for KB and MCF-7 human cancer cell lines. The results showed that (S)-enantiomers were more active than (R)-enantiomers and the different positions of methoxy group in salicyl ring gave different cytotoxicities. |
| format | Article |
| id | doaj-art-1ffbc398176f4eb096d5563b6755bc0a |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-1ffbc398176f4eb096d5563b6755bc0a2025-08-20T03:54:43ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/54149595414959Synthesis, Characterization, and In Vitro Cytotoxicity of Platinum(II) Complexes Bearing Chiral Tetradentate Salicylaldimine LigandsQuang Trung Nguyen0Phuong Nam Pham Thi1Van Tuyen Nguyen2Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, VietnamInstitute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, VietnamInstitute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, VietnamA series of platinum(II) complexes with chiral Schiff base ligands derived from various salicylaldehydes with (R,R′)- and (S,S′)-cyclohexanediamine were synthesized and characterized by ESI-MS, IR, and NMR. Obtained spectra with typical signals were in agreement with suggested molecular formulae of the complexes. Their photophysical properties were studied by UV-visible and emission spectroscopies. The UV-Vis showed the typical band with low energy at visible range 400–500 nm for MLCT, and this band can emit the luminescent band with emission maximum wavelengths at 529–595 nm. The in vitro cytotoxicity of obtained platinum(II) complexes was screened for KB and MCF-7 human cancer cell lines. The results showed that (S)-enantiomers were more active than (R)-enantiomers and the different positions of methoxy group in salicyl ring gave different cytotoxicities.http://dx.doi.org/10.1155/2020/5414959 |
| spellingShingle | Quang Trung Nguyen Phuong Nam Pham Thi Van Tuyen Nguyen Synthesis, Characterization, and In Vitro Cytotoxicity of Platinum(II) Complexes Bearing Chiral Tetradentate Salicylaldimine Ligands Journal of Chemistry |
| title | Synthesis, Characterization, and In Vitro Cytotoxicity of Platinum(II) Complexes Bearing Chiral Tetradentate Salicylaldimine Ligands |
| title_full | Synthesis, Characterization, and In Vitro Cytotoxicity of Platinum(II) Complexes Bearing Chiral Tetradentate Salicylaldimine Ligands |
| title_fullStr | Synthesis, Characterization, and In Vitro Cytotoxicity of Platinum(II) Complexes Bearing Chiral Tetradentate Salicylaldimine Ligands |
| title_full_unstemmed | Synthesis, Characterization, and In Vitro Cytotoxicity of Platinum(II) Complexes Bearing Chiral Tetradentate Salicylaldimine Ligands |
| title_short | Synthesis, Characterization, and In Vitro Cytotoxicity of Platinum(II) Complexes Bearing Chiral Tetradentate Salicylaldimine Ligands |
| title_sort | synthesis characterization and in vitro cytotoxicity of platinum ii complexes bearing chiral tetradentate salicylaldimine ligands |
| url | http://dx.doi.org/10.1155/2020/5414959 |
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