Organoid-on-a-chip (OrgOC): Advancing cystic fibrosis research
Cystic fibrosis (CF) is an autosomal recessive disorder resulting from impaired anion transport in the epithelium of multiple organs, thereby affecting various physiological functions throughout the body. The heterogeneity of CF complicates drug development, highlighting the growing importance of in...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-10-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425007185 |
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| author | Minjie Zheng Elisa Erice Huiyi Wang Lei Zhang Charles H. Lawrie |
| author_facet | Minjie Zheng Elisa Erice Huiyi Wang Lei Zhang Charles H. Lawrie |
| author_sort | Minjie Zheng |
| collection | DOAJ |
| description | Cystic fibrosis (CF) is an autosomal recessive disorder resulting from impaired anion transport in the epithelium of multiple organs, thereby affecting various physiological functions throughout the body. The heterogeneity of CF complicates drug development, highlighting the growing importance of individualized therapies. CF patient-derived organoid models and organ-on-a-chip (OOC) platforms are promising in vitro models for recapitulating CF pathology, owing to their high simulation fidelity, individualized therapeutic capabilities, cost-effectiveness, and high-throughput screening potential. This review systematically summarizes the technological development pathways of patient-derived organoids and OOC platforms for CF, along with recent advances in their applications to CF-related basic research, and particularly focuses on exploratory studies using organoid-on-a-chip (OrgOC) systems to elucidate CF pathogenesis and assess therapeutic approaches. |
| format | Article |
| id | doaj-art-1ffa90fc48084ad4b513cab14be3bac0 |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-1ffa90fc48084ad4b513cab14be3bac02025-08-20T02:47:28ZengElsevierMaterials Today Bio2590-00642025-10-013410214810.1016/j.mtbio.2025.102148Organoid-on-a-chip (OrgOC): Advancing cystic fibrosis researchMinjie Zheng0Elisa Erice1Huiyi Wang2Lei Zhang3Charles H. Lawrie4School of Microelectronics, Shanghai University, Shanghai, 201800, China; Sino-Swiss Institute of Advanced Technology (SSIAT), Shanghai University, Shanghai, 201800, ChinaSino-Swiss Institute of Advanced Technology (SSIAT), Shanghai University, Shanghai, 201800, ChinaSino-Swiss Institute of Advanced Technology (SSIAT), Shanghai University, Shanghai, 201800, ChinaSchool of Microelectronics, Shanghai University, Shanghai, 201800, China; Sino-Swiss Institute of Advanced Technology (SSIAT), Shanghai University, Shanghai, 201800, China; Corresponding author. School of Microelectronics, Shanghai University, Shanghai, 201800, China.Sino-Swiss Institute of Advanced Technology (SSIAT), Shanghai University, Shanghai, 201800, China; Molecular Oncology Group, Biogipuzkoa Research Institute, Paseo Doctor Begiristain, San Sebastián, 20014, Spain; Corresponding author. Sino-Swiss Institute of Advanced Technology (SSIAT), Shanghai University, Shanghai, 201800, China.Cystic fibrosis (CF) is an autosomal recessive disorder resulting from impaired anion transport in the epithelium of multiple organs, thereby affecting various physiological functions throughout the body. The heterogeneity of CF complicates drug development, highlighting the growing importance of individualized therapies. CF patient-derived organoid models and organ-on-a-chip (OOC) platforms are promising in vitro models for recapitulating CF pathology, owing to their high simulation fidelity, individualized therapeutic capabilities, cost-effectiveness, and high-throughput screening potential. This review systematically summarizes the technological development pathways of patient-derived organoids and OOC platforms for CF, along with recent advances in their applications to CF-related basic research, and particularly focuses on exploratory studies using organoid-on-a-chip (OrgOC) systems to elucidate CF pathogenesis and assess therapeutic approaches.http://www.sciencedirect.com/science/article/pii/S2590006425007185Cystic fibrosisOrgan-on-a-chipOrganoidOrganoid-on-a-chip |
| spellingShingle | Minjie Zheng Elisa Erice Huiyi Wang Lei Zhang Charles H. Lawrie Organoid-on-a-chip (OrgOC): Advancing cystic fibrosis research Materials Today Bio Cystic fibrosis Organ-on-a-chip Organoid Organoid-on-a-chip |
| title | Organoid-on-a-chip (OrgOC): Advancing cystic fibrosis research |
| title_full | Organoid-on-a-chip (OrgOC): Advancing cystic fibrosis research |
| title_fullStr | Organoid-on-a-chip (OrgOC): Advancing cystic fibrosis research |
| title_full_unstemmed | Organoid-on-a-chip (OrgOC): Advancing cystic fibrosis research |
| title_short | Organoid-on-a-chip (OrgOC): Advancing cystic fibrosis research |
| title_sort | organoid on a chip orgoc advancing cystic fibrosis research |
| topic | Cystic fibrosis Organ-on-a-chip Organoid Organoid-on-a-chip |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425007185 |
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