Pan-Cancer Exome-wide analysis of germline mutational patterns and pathways

Pan-Cancer Exome-wide analysis of germline mutational patterns and pathways

Abstract Cancer progression and development are influenced by a complex interplay between inherited (germline) and acquired (somatic) mutations. Current cancer genomic research in Middle Eastern populations predominantly utilizes targeted panels to examine predefined genes, potentially overlooking a...

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Bibliographic Details
Main Authors: Halima Alnaqbi, Michael Olbrich, Noora Zayed, Mira Mousa, Sarah Azzam, Syed Hammad Tirmazy, Habiba Alsafar
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Cancer
Germline
Mutations
Whole exome sequencing
Online Access:https://doi.org/10.1038/s41598-025-05296-3
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