Pharmaceutical Development and Analysis of Polyherbal Formulations as Ashmaghna Kwatha and Ashmaghna Ghana Vati and Comparative In-vitro Assessment of their Anti-urolithiatic Activity: A Research Protocol
Introduction: Urolithiasis, also known as Mutrashmari, is the formation of urinary stones in the urinary system. Ayurveda has also studied traditional herbs for their anti-urolithiasis effects, including Ashmaghna decoction and Ashmaghna tablet, developed using specific drugs mentioned in the Ashmar...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2025-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/20895/73484_151224_73484_CE[Ra1]_F(SL)_PF1(VD_IS_OM)_redo_PFA_NC(IS)_PN(IS).pdf |
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| Summary: | Introduction: Urolithiasis, also known as Mutrashmari, is the formation of urinary stones in the urinary system. Ayurveda has also studied traditional herbs for their anti-urolithiasis effects, including Ashmaghna decoction and Ashmaghna tablet, developed using specific drugs mentioned in the Ashmari Rogadhikar chapter of Bhaishajya Ratnawali. The decoction is for oral administration, while the tablet is a modified dosage form of the decoction.
Need of the study: Recent studies show a rising incidence of urolithiasis globally, linked to lifestyle changes like reduced physical activity and altered diets. Various treatments, including lithotripsy and hydrotherapy, are used, but Acharya Sushrut advocated oral remedies, such as medicated decoctions and ghee oils, as initial treatments before surgery.
Aim: To assess the pharmaceutical-analytical development of polyherbal formulations, Ashmaghna Kwatha and Ashmaghna Ghana Vati, and comparative in-vitro assessment of their anti-urolithiatic activity.
Materials and Methods: An experimental study will be carried out at Datta Meghe Institute of Higher Education and Research (MGACH and RC), Salod (H), Wardha, in the Department of Rasashashtra and Bhaishajya Kalpana from Jan 2024 to Dec 2024. All herbal drugs will be collected, and authenticated by the department of Dravyaguna. Ashmaghna decoction (Kwatha) and Ashmaghna tablet (Ghana Vati) will be prepared by the Department of Rasa Shastra and Bhaishajya Kalpana as per reference in Sharangdhar Samhita. In-vitro assessment model will be done using aggregation and nucleation assays. For the anti-urolithiatic activity of drugs, statistical analysis will be done using paired t-tests, for intragroup comparison and unpaired t-test for intergroup comparison. A p<0.05 will be considered significant. |
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| ISSN: | 2249-782X 0973-709X |