Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review
Traditionally, Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), a pivotal class of drug, mimics the actions of endogenous Glucagon-like peptide-1, which have been found to be remarkable in the treatment of type 2 diabetes alongside other comorbidities. GLP-1 receptors being widely avail...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Clinical Diabetes and Healthcare |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcdhc.2025.1590530/full |
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| author | Bisma Fatima Hammad Nimrah Zafar Muneeb Ullah Syeda Jazilah Faisal Fizzah Iftikhar Haadia Waheed Muhammad Waleed Muzaffar Khadija Ahmed Faz Ashraf Komal Zahid Maimoona Akhtar Mohammed Mahmmoud Fadelallah Eljack |
| author_facet | Bisma Fatima Hammad Nimrah Zafar Muneeb Ullah Syeda Jazilah Faisal Fizzah Iftikhar Haadia Waheed Muhammad Waleed Muzaffar Khadija Ahmed Faz Ashraf Komal Zahid Maimoona Akhtar Mohammed Mahmmoud Fadelallah Eljack |
| author_sort | Bisma Fatima Hammad |
| collection | DOAJ |
| description | Traditionally, Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), a pivotal class of drug, mimics the actions of endogenous Glucagon-like peptide-1, which have been found to be remarkable in the treatment of type 2 diabetes alongside other comorbidities. GLP-1 receptors being widely available in the different organs and tissues such as the brain, lung, pancreas, stomach, heart, and endometrium has explained the broader therapeutic application of GLP-1RA. The recent studies have explored the physiological effects of GLP-1RA on body organs, establishing them as a potential therapeutic option for a wide range of diseases. Activation of GLP-1 receptors contribute to regulation of blood glucose levels, weight management, cardiovascular health, and potential neuroprotection, while also having a positive influence on musculoskeletal health. This review has emphasized the expanded role of GLP-1RA by highlighting the most significant and notable studies. While GLP-1RA has proven clinical efficacy, the need for more comprehensive studies, to ensure their long-term safety, is essential to optimize their therapeutic role and improve patient outcomes on a global scale. Addressing the significant gap for research on cost effectiveness of these drugs is also crucial for their accessibility in comparison to other drugs. Nevertheless, the limited data available calls for a platform for future research to carry out the expanded therapeutic effects of GLP-1RA. |
| format | Article |
| id | doaj-art-1ff353ab055f482eba8f3e05b4b15bbf |
| institution | Kabale University |
| issn | 2673-6616 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Clinical Diabetes and Healthcare |
| spelling | doaj-art-1ff353ab055f482eba8f3e05b4b15bbf2025-08-20T03:29:03ZengFrontiers Media S.A.Frontiers in Clinical Diabetes and Healthcare2673-66162025-07-01610.3389/fcdhc.2025.15905301590530Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive reviewBisma Fatima Hammad0Nimrah Zafar1Muneeb Ullah2Syeda Jazilah Faisal3Fizzah Iftikhar4Haadia Waheed5Muhammad Waleed Muzaffar6Khadija Ahmed7Faz Ashraf8Komal Zahid9Maimoona Akhtar10Mohammed Mahmmoud Fadelallah Eljack11Hammad Department of Medicine, Liaquat National Hospital and Medical College, Karachi, PakistanDepartment of Medicine, Dow University of Health Sciences, Karachi, PakistanDepartment of Medicine, Saidu Medical College, Swat, PakistanDepartment of Medicine, Dow Medical College, Karachi, PakistanDepartment of Medicine, Karachi Medical and Dental College, Karachi, PakistanDepartment of Medicine, Dow International Medical College, Karachi, PakistanDepartment of Medicine, Niazi Medical and Dental College, Sargodha, PakistanDepartment of Medicine, Dow Medical College, Karachi, PakistanDepartment of Medicine, Rashid Latif Medical College, Lahore, PakistanDepartment of Medicine, Women Medical and Dental College, Abbottabad, PakistanDepartment of Medicine, Karachi Medical and Dental College, Karachi, Pakistan0Community Department, University of Bakht Alruda, Ad Duwaym, SudanTraditionally, Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), a pivotal class of drug, mimics the actions of endogenous Glucagon-like peptide-1, which have been found to be remarkable in the treatment of type 2 diabetes alongside other comorbidities. GLP-1 receptors being widely available in the different organs and tissues such as the brain, lung, pancreas, stomach, heart, and endometrium has explained the broader therapeutic application of GLP-1RA. The recent studies have explored the physiological effects of GLP-1RA on body organs, establishing them as a potential therapeutic option for a wide range of diseases. Activation of GLP-1 receptors contribute to regulation of blood glucose levels, weight management, cardiovascular health, and potential neuroprotection, while also having a positive influence on musculoskeletal health. This review has emphasized the expanded role of GLP-1RA by highlighting the most significant and notable studies. While GLP-1RA has proven clinical efficacy, the need for more comprehensive studies, to ensure their long-term safety, is essential to optimize their therapeutic role and improve patient outcomes on a global scale. Addressing the significant gap for research on cost effectiveness of these drugs is also crucial for their accessibility in comparison to other drugs. Nevertheless, the limited data available calls for a platform for future research to carry out the expanded therapeutic effects of GLP-1RA.https://www.frontiersin.org/articles/10.3389/fcdhc.2025.1590530/fullglucagon-like peptide-1type 2 diabetesendothelial functionobesitymetabolic syndrome |
| spellingShingle | Bisma Fatima Hammad Nimrah Zafar Muneeb Ullah Syeda Jazilah Faisal Fizzah Iftikhar Haadia Waheed Muhammad Waleed Muzaffar Khadija Ahmed Faz Ashraf Komal Zahid Maimoona Akhtar Mohammed Mahmmoud Fadelallah Eljack Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review Frontiers in Clinical Diabetes and Healthcare glucagon-like peptide-1 type 2 diabetes endothelial function obesity metabolic syndrome |
| title | Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review |
| title_full | Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review |
| title_fullStr | Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review |
| title_full_unstemmed | Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review |
| title_short | Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review |
| title_sort | exploring the multifaceted roles of glp 1 receptor agonists a comprehensive review |
| topic | glucagon-like peptide-1 type 2 diabetes endothelial function obesity metabolic syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fcdhc.2025.1590530/full |
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