Translational repression in malaria sporozoites
Malaria is a mosquito-borne infectious disease of humans and other animals. It is caused by the parasitic protozoan, Plasmodium. Sporozoites, the infectious form of malaria parasites, are quiescent when they remain in the salivary glands of the Anopheles mosquito until transmission into a mammalian...
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Shared Science Publishers OG
2016-04-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/translational-repression-in-malaria-sporozoites/ |
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| author | Oliver Turque Tiffany Tsao Thomas Li Min Zhang |
| author_facet | Oliver Turque Tiffany Tsao Thomas Li Min Zhang |
| author_sort | Oliver Turque |
| collection | DOAJ |
| description | Malaria is a mosquito-borne infectious disease of humans and other animals. It is caused by the parasitic protozoan, Plasmodium. Sporozoites, the infectious form of malaria parasites, are quiescent when they remain in the salivary glands of the Anopheles mosquito until transmission into a mammalian host. Metamorphosis of the dormant sporozoite to its active form in the liver stage requires transcriptional and translational regulations. Here, we summarize recent advances in the translational repression of gene expression in the malaria sporozoite. In sporozoites, many mRNAs that are required for liver stage development are translationally repressed. Phosphorylation of eukaryotic Initiation Factor 2α (eIF2α) leads to a global translational repression in sporozoites. The eIF2α kinase, known as Upregulated in Infectious Sporozoite 1 (UIS1), is dominant in the sporozoite. The eIF2α phosphatase, UIS2, is translationally repressed by the Pumilio protein Puf2. This translational repression is alleviated when sporozoites are delivered into the mammalian host. |
| format | Article |
| id | doaj-art-1ff0dcfab0fe45be9b4e845e9ac40d24 |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2016-04-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-1ff0dcfab0fe45be9b4e845e9ac40d242025-08-20T02:53:21ZengShared Science Publishers OGMicrobial Cell2311-26382016-04-013522722910.15698/mic2016.05.502Translational repression in malaria sporozoitesOliver Turque0Tiffany Tsao1Thomas Li2Min Zhang3HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY, USA.HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY, USA.HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY, USA.HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY, USA.Malaria is a mosquito-borne infectious disease of humans and other animals. It is caused by the parasitic protozoan, Plasmodium. Sporozoites, the infectious form of malaria parasites, are quiescent when they remain in the salivary glands of the Anopheles mosquito until transmission into a mammalian host. Metamorphosis of the dormant sporozoite to its active form in the liver stage requires transcriptional and translational regulations. Here, we summarize recent advances in the translational repression of gene expression in the malaria sporozoite. In sporozoites, many mRNAs that are required for liver stage development are translationally repressed. Phosphorylation of eukaryotic Initiation Factor 2α (eIF2α) leads to a global translational repression in sporozoites. The eIF2α kinase, known as Upregulated in Infectious Sporozoite 1 (UIS1), is dominant in the sporozoite. The eIF2α phosphatase, UIS2, is translationally repressed by the Pumilio protein Puf2. This translational repression is alleviated when sporozoites are delivered into the mammalian host.http://microbialcell.com/researcharticles/translational-repression-in-malaria-sporozoites/PlasmodiumsporozoiteslatencyeIF2αUIS1UIS2translational repression |
| spellingShingle | Oliver Turque Tiffany Tsao Thomas Li Min Zhang Translational repression in malaria sporozoites Microbial Cell Plasmodium sporozoites latency eIF2α UIS1 UIS2 translational repression |
| title | Translational repression in malaria sporozoites |
| title_full | Translational repression in malaria sporozoites |
| title_fullStr | Translational repression in malaria sporozoites |
| title_full_unstemmed | Translational repression in malaria sporozoites |
| title_short | Translational repression in malaria sporozoites |
| title_sort | translational repression in malaria sporozoites |
| topic | Plasmodium sporozoites latency eIF2α UIS1 UIS2 translational repression |
| url | http://microbialcell.com/researcharticles/translational-repression-in-malaria-sporozoites/ |
| work_keys_str_mv | AT oliverturque translationalrepressioninmalariasporozoites AT tiffanytsao translationalrepressioninmalariasporozoites AT thomasli translationalrepressioninmalariasporozoites AT minzhang translationalrepressioninmalariasporozoites |