Polymorphism study of MTHFR 677C→T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq
This research includes a study of Methylenetetrahydrofolate reductase gene’s allele 677C→T and its correlation with oxidative stress and their impact on female infertility. Fifty infertile women with the range age (23-42) years and twenty five fertile women with the range age (22-39) years as contro...
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| Format: | Article |
| Language: | English |
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University of Baghdad, College of Science for Women
2017-10-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://www.csw-journal.org/show-articles.php?id_article=1991 |
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| author | Muthanna A. Thabit Gaylany H. Abdullah Khalid F. AL-Rawi1 |
| author_facet | Muthanna A. Thabit Gaylany H. Abdullah Khalid F. AL-Rawi1 |
| author_sort | Muthanna A. Thabit |
| collection | DOAJ |
| description | This research includes a study of Methylenetetrahydrofolate reductase gene’s allele 677C→T and its correlation with oxidative stress and their impact on female infertility. Fifty infertile women with the range age (23-42) years and twenty five fertile women with the range age (22-39) years as control group living in Erbil city were selected. The serum level of Malondialdehyde (MDA), superoxide dismutase (SOD), prolactin hormone (PRL), Luteinizing hormone (LH), Thyroid stimulating hormone (TSH), Triiodothyronine hormone (T3), and Thyroxine hormone (T4) were measured, also a body mass index (BMI) was calculated. A restriction enzyme (Hinf1) was used to improve the mutation in DNA bands of infertile women. The results showed significant increases in MDA level, SOD activity, BMI, PRL, LH, TSH, and T4 in patients women compared with the control group. The results show non-significant differences in T3 hormone levels. The results also show a mutation in DNA bands of infertile women compared with fertile control group |
| format | Article |
| id | doaj-art-1feff7910d2649fd810fea6edd598023 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-1feff7910d2649fd810fea6edd5980232025-08-20T03:58:08ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862017-10-0114361161810.21123/bsj.2017.14.3.0611Polymorphism study of MTHFR 677C→T and its correlation with oxidative stress and their influence on female infertility in Erbil – IraqMuthanna A. Thabit0Gaylany H. Abdullah 1Khalid F. AL-Rawi12Department of Chemistry, College of Science, University of Anbar, Al-Anbar, IraqMedical research center, Hawler Medical University, Erbil, Iraq.Department of Chemistry, College of Science, University of Anbar, Al-Anbar, IraqThis research includes a study of Methylenetetrahydrofolate reductase gene’s allele 677C→T and its correlation with oxidative stress and their impact on female infertility. Fifty infertile women with the range age (23-42) years and twenty five fertile women with the range age (22-39) years as control group living in Erbil city were selected. The serum level of Malondialdehyde (MDA), superoxide dismutase (SOD), prolactin hormone (PRL), Luteinizing hormone (LH), Thyroid stimulating hormone (TSH), Triiodothyronine hormone (T3), and Thyroxine hormone (T4) were measured, also a body mass index (BMI) was calculated. A restriction enzyme (Hinf1) was used to improve the mutation in DNA bands of infertile women. The results showed significant increases in MDA level, SOD activity, BMI, PRL, LH, TSH, and T4 in patients women compared with the control group. The results show non-significant differences in T3 hormone levels. The results also show a mutation in DNA bands of infertile women compared with fertile control grouphttp://www.csw-journal.org/show-articles.php?id_article=1991Female infertility (FI)Methylenetetrahydrofolate reductase (MTHFR) geneOxidative stress (OS). |
| spellingShingle | Muthanna A. Thabit Gaylany H. Abdullah Khalid F. AL-Rawi1 Polymorphism study of MTHFR 677C→T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq مجلة بغداد للعلوم Female infertility (FI) Methylenetetrahydrofolate reductase (MTHFR) gene Oxidative stress (OS). |
| title | Polymorphism study of MTHFR 677C→T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq |
| title_full | Polymorphism study of MTHFR 677C→T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq |
| title_fullStr | Polymorphism study of MTHFR 677C→T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq |
| title_full_unstemmed | Polymorphism study of MTHFR 677C→T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq |
| title_short | Polymorphism study of MTHFR 677C→T and its correlation with oxidative stress and their influence on female infertility in Erbil – Iraq |
| title_sort | polymorphism study of mthfr 677c t and its correlation with oxidative stress and their influence on female infertility in erbil iraq |
| topic | Female infertility (FI) Methylenetetrahydrofolate reductase (MTHFR) gene Oxidative stress (OS). |
| url | http://www.csw-journal.org/show-articles.php?id_article=1991 |
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