hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling

hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling

Abstract Background Cavernous nerve injury-induced erectile dysfunction (CNI-ED) is a common complication following radical prostatectomy and severely affects patients’ quality of life. The mitochondrial impairment in corpus cavernosum smooth muscle cells (CCSMCs) may be an important pathological me...

Full description

Saved in:
Bibliographic Details
Main Authors: Mengbo Yang, Xinda Chen, Ming Zhang, Xiaolin Zhang, Dongdong Xiao, Huiming Xu, Mujun Lu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biological Research
Subjects:
Cavernous nerve injury-induced erectile dysfunction
Corpus cavernous smooth muscle cell
Mesenchymal stem cell
SIRT1/PGC-1α/TFAM pathway
Online Access:https://doi.org/10.1186/s40659-024-00578-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items