Tissue-Engineered Tracheal Reconstruction
Tracheal reconstruction remains a formidable clinical challenge, particularly for long-segment defects that are not amenable to standard surgical resection or primary anastomosis. Tissue engineering has emerged as a promising strategy for restoring the tracheal structure and function through the int...
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MDPI AG
2025-07-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/10/7/457 |
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| author | Se Hyun Yeou Yoo Seob Shin |
| author_facet | Se Hyun Yeou Yoo Seob Shin |
| author_sort | Se Hyun Yeou |
| collection | DOAJ |
| description | Tracheal reconstruction remains a formidable clinical challenge, particularly for long-segment defects that are not amenable to standard surgical resection or primary anastomosis. Tissue engineering has emerged as a promising strategy for restoring the tracheal structure and function through the integration of biomaterials, stem cells, and bioactive molecules. This review provides a comprehensive overview of recent advances in tissue-engineered tracheal grafts, particularly in scaffold design, cellular sources, fabrication technologies, and early clinical experience. Innovations in biomaterial science, three-dimensional printing, and scaffold-free fabrication approaches have broadened the prospects for patient-specific airway reconstruction. However, persistent challenges, including incomplete epithelial regeneration and mechanical instability, have hindered its clinical translation. Future efforts should focus on the design of modular biomimetic scaffolds, the enhancement of immunomodulatory strategies, and preclinical validation using robust large animal models. Sustained interdisciplinary collaboration among surgical, engineering, and biological fields is crucial for advancing tissue-engineered tracheal grafts for routine clinical applications. Within this context, biomimetic approaches, including three-dimensional bioprinting, hybrid materials, and scaffold-free constructs, are gaining prominence as strategies to replicate the trachea’s native architecture and improve graft integration. |
| format | Article |
| id | doaj-art-1fea6bef113b438b827c95ff1e2f7a7d |
| institution | DOAJ |
| issn | 2313-7673 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj-art-1fea6bef113b438b827c95ff1e2f7a7d2025-08-20T03:07:57ZengMDPI AGBiomimetics2313-76732025-07-0110745710.3390/biomimetics10070457Tissue-Engineered Tracheal ReconstructionSe Hyun Yeou0Yoo Seob Shin1Department of Otorhinolaryngology-Head and Neck Surgery, Ajou University School of Medicine, Suwon 16499, Republic of KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Ajou University School of Medicine, Suwon 16499, Republic of KoreaTracheal reconstruction remains a formidable clinical challenge, particularly for long-segment defects that are not amenable to standard surgical resection or primary anastomosis. Tissue engineering has emerged as a promising strategy for restoring the tracheal structure and function through the integration of biomaterials, stem cells, and bioactive molecules. This review provides a comprehensive overview of recent advances in tissue-engineered tracheal grafts, particularly in scaffold design, cellular sources, fabrication technologies, and early clinical experience. Innovations in biomaterial science, three-dimensional printing, and scaffold-free fabrication approaches have broadened the prospects for patient-specific airway reconstruction. However, persistent challenges, including incomplete epithelial regeneration and mechanical instability, have hindered its clinical translation. Future efforts should focus on the design of modular biomimetic scaffolds, the enhancement of immunomodulatory strategies, and preclinical validation using robust large animal models. Sustained interdisciplinary collaboration among surgical, engineering, and biological fields is crucial for advancing tissue-engineered tracheal grafts for routine clinical applications. Within this context, biomimetic approaches, including three-dimensional bioprinting, hybrid materials, and scaffold-free constructs, are gaining prominence as strategies to replicate the trachea’s native architecture and improve graft integration.https://www.mdpi.com/2313-7673/10/7/457regenerative medicinetracheal reconstructiontissue engineeringscaffoldstem cells |
| spellingShingle | Se Hyun Yeou Yoo Seob Shin Tissue-Engineered Tracheal Reconstruction Biomimetics regenerative medicine tracheal reconstruction tissue engineering scaffold stem cells |
| title | Tissue-Engineered Tracheal Reconstruction |
| title_full | Tissue-Engineered Tracheal Reconstruction |
| title_fullStr | Tissue-Engineered Tracheal Reconstruction |
| title_full_unstemmed | Tissue-Engineered Tracheal Reconstruction |
| title_short | Tissue-Engineered Tracheal Reconstruction |
| title_sort | tissue engineered tracheal reconstruction |
| topic | regenerative medicine tracheal reconstruction tissue engineering scaffold stem cells |
| url | https://www.mdpi.com/2313-7673/10/7/457 |
| work_keys_str_mv | AT sehyunyeou tissueengineeredtrachealreconstruction AT yooseobshin tissueengineeredtrachealreconstruction |