Interaction of immune response mediator genes in a predisposition to juvenile idiopathic arthritis
Background/objective — The goal of our study was to investigate the role of interaction between the polymorphic loci of immune response mediator genes (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1...
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| Format: | Article |
| Language: | English |
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Limited liability company «Science and Innovations» (Saratov)
2022-09-01
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| Series: | Russian Open Medical Journal |
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| Online Access: | https://romj.org/node/478 |
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| author | Liliia Sh. Nazarova Ksenia V. Danilko Viktor A. Malievsky Denis O. Karimov Akhat B. Bakirov Tatyana V. Viktorova |
| author_facet | Liliia Sh. Nazarova Ksenia V. Danilko Viktor A. Malievsky Denis O. Karimov Akhat B. Bakirov Tatyana V. Viktorova |
| author_sort | Liliia Sh. Nazarova |
| collection | DOAJ |
| description | Background/objective — The goal of our study was to investigate the role of interaction between the polymorphic loci of immune response mediator genes (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, and PADI4 rs2240336) in the formation of a genetic predisposition to juvenile idiopathic arthritis (JIA).
Material and Methods — The study involved 330 JIA patients and 342 volunteers from the Republic of Bashkortostan. Genotyping was conducted via the real-time polymerase chain reaction. The gene-gene interactions were studied using the multifactor dimensionality reduction algorithm.
Results — In general analysis, the best model of gene-gene interaction in JIA was a combination of IL1B rs16944 – IL10 rs1800872 – NFKB1 rs28362491 – PADI4 rs2240336 polymorphic loci. However, after gender-based stratification the best results were obtained when examining the combinations of IL6 rs1800795 – PADI4 rs2240336 loci in girls and of IL10 rs1800872 – IL6 rs1800795 – IL2RA rs2104286 loci in boys. Within all of these models, the genotype combinations associated with both augmented and reduced JIA risks were identified (taking into account gender-specific differences).
Conclusion — The results of our study implied that an important role in the formation of a predisposition to JIA is played by gene-gene interactions of IL1B rs16944, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, NFKB1 rs28362491, and PADI4 rs2240336 polymorphic loci (taking into account gender-specific differences). |
| format | Article |
| id | doaj-art-1fe8b73ed8fc49e99035ebdd596f72fe |
| institution | DOAJ |
| issn | 2304-3415 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj-art-1fe8b73ed8fc49e99035ebdd596f72fe2025-08-20T03:07:32ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152022-09-01113e031110.15275/rusomj.2022.0311Interaction of immune response mediator genes in a predisposition to juvenile idiopathic arthritisLiliia Sh. NazarovaKsenia V. DanilkoViktor A. MalievskyDenis O. KarimovAkhat B. BakirovTatyana V. ViktorovaBackground/objective — The goal of our study was to investigate the role of interaction between the polymorphic loci of immune response mediator genes (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, and PADI4 rs2240336) in the formation of a genetic predisposition to juvenile idiopathic arthritis (JIA). Material and Methods — The study involved 330 JIA patients and 342 volunteers from the Republic of Bashkortostan. Genotyping was conducted via the real-time polymerase chain reaction. The gene-gene interactions were studied using the multifactor dimensionality reduction algorithm. Results — In general analysis, the best model of gene-gene interaction in JIA was a combination of IL1B rs16944 – IL10 rs1800872 – NFKB1 rs28362491 – PADI4 rs2240336 polymorphic loci. However, after gender-based stratification the best results were obtained when examining the combinations of IL6 rs1800795 – PADI4 rs2240336 loci in girls and of IL10 rs1800872 – IL6 rs1800795 – IL2RA rs2104286 loci in boys. Within all of these models, the genotype combinations associated with both augmented and reduced JIA risks were identified (taking into account gender-specific differences). Conclusion — The results of our study implied that an important role in the formation of a predisposition to JIA is played by gene-gene interactions of IL1B rs16944, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, NFKB1 rs28362491, and PADI4 rs2240336 polymorphic loci (taking into account gender-specific differences).https://romj.org/node/478juvenile idiopathic arthritispolymorphic lociimmune systemgeneticsgene-gene interactionsmultifactor dimensionality reduction algorithm |
| spellingShingle | Liliia Sh. Nazarova Ksenia V. Danilko Viktor A. Malievsky Denis O. Karimov Akhat B. Bakirov Tatyana V. Viktorova Interaction of immune response mediator genes in a predisposition to juvenile idiopathic arthritis Russian Open Medical Journal juvenile idiopathic arthritis polymorphic loci immune system genetics gene-gene interactions multifactor dimensionality reduction algorithm |
| title | Interaction of immune response mediator genes in a predisposition to juvenile idiopathic arthritis |
| title_full | Interaction of immune response mediator genes in a predisposition to juvenile idiopathic arthritis |
| title_fullStr | Interaction of immune response mediator genes in a predisposition to juvenile idiopathic arthritis |
| title_full_unstemmed | Interaction of immune response mediator genes in a predisposition to juvenile idiopathic arthritis |
| title_short | Interaction of immune response mediator genes in a predisposition to juvenile idiopathic arthritis |
| title_sort | interaction of immune response mediator genes in a predisposition to juvenile idiopathic arthritis |
| topic | juvenile idiopathic arthritis polymorphic loci immune system genetics gene-gene interactions multifactor dimensionality reduction algorithm |
| url | https://romj.org/node/478 |
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