Disturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with HIV-1 and on antiretroviral therapy at Bafoussam Regional Hospital, Cameroon
Abstract Background This study investigates the gut microbiota components associated with metabolic syndrome in patients living with HIV-1 at Bafoussam Regional Hospital, West Cameroon, it focuses on gastrointestinal mucosal barrier disruption and dysbiosis, and their effects on persistent inflammat...
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BMC
2025-03-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01653-4 |
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| author | Joël Martial Diesse Sushama Jadhav Stephen Lacmata Tamekou Gustave Simo Jean Paul Dzoyem Jacob Souopgui Jules-Roger Kuiate Vijay Nema |
| author_facet | Joël Martial Diesse Sushama Jadhav Stephen Lacmata Tamekou Gustave Simo Jean Paul Dzoyem Jacob Souopgui Jules-Roger Kuiate Vijay Nema |
| author_sort | Joël Martial Diesse |
| collection | DOAJ |
| description | Abstract Background This study investigates the gut microbiota components associated with metabolic syndrome in patients living with HIV-1 at Bafoussam Regional Hospital, West Cameroon, it focuses on gastrointestinal mucosal barrier disruption and dysbiosis, and their effects on persistent inflammation and metabolic disorders. Methods A pilot study was conducted involving fourteen patients living with HIV-1. The patients were divided into two groups of seven in each group. One group consisted of patients with metabolic syndrome, and the other group included patients without metabolic syndrome. Gut microbiota was characterized using 16 S rRNA gene-targeted sequencing to analyze microbial diversity and composition. Beta diversity and the relative abundance of bacterial taxa were compared between patients with and without metabolic syndrome. Results Patients living with HIV-1 and metabolic syndrome showed significantly altered beta diversity compared to those without metabolic syndrome. A higher relative abundance of Firmicutes and increased proliferation of Proteobacteria were observed in patients with metabolic syndrome. Additionally, a decrease in metabolically beneficial bacteria, such as Bifidobacterium sp., Lactobacillus sp., Akkermansia sp., and Faecalibacterium sp., was noted. Several beneficial bacterial species were associated with participants' metadata, suggesting potential links between gut microbiota and metabolic syndrome. Conclusion This preliminary study highlights that gut microbial balance, rather than the presence of specific bacteria, plays a crucial role in managing metabolic health in patients living with HIV-1. The altered gut microbiota in participants with metabolic syndrome emphasizes the need for further research into the optimal gut microbial structure. Understanding the interaction between gut microbiota changes and the chemical environment in these patients could guide targeted interventions to improve metabolic outcomes. |
| format | Article |
| id | doaj-art-1fe61c0915134de9beb58d5d6e713ef3 |
| institution | DOAJ |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-1fe61c0915134de9beb58d5d6e713ef32025-08-20T02:56:15ZengBMCDiabetology & Metabolic Syndrome1758-59962025-03-0117111310.1186/s13098-025-01653-4Disturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with HIV-1 and on antiretroviral therapy at Bafoussam Regional Hospital, CameroonJoël Martial Diesse0Sushama Jadhav1Stephen Lacmata Tamekou2Gustave Simo3Jean Paul Dzoyem4Jacob Souopgui5Jules-Roger Kuiate6Vijay Nema7Department of Biochemistry, Faculty of Science, University of DschangDivision of Molecular Biology, Indian Council of Medical Research - National Institute of Translational Virology and AIDS Research Department of Biochemistry, Faculty of Science, University of DschangDepartment of Biochemistry, Faculty of Science, University of DschangDepartment of Biochemistry, Faculty of Science, University of DschangLaboratory of Embryology & Biotechnology DBM-IBMM, “Université Libre de Bruxelles”Department of Biochemistry, Faculty of Science, University of DschangDivision of Molecular Biology, Indian Council of Medical Research - National Institute of Translational Virology and AIDS Research Abstract Background This study investigates the gut microbiota components associated with metabolic syndrome in patients living with HIV-1 at Bafoussam Regional Hospital, West Cameroon, it focuses on gastrointestinal mucosal barrier disruption and dysbiosis, and their effects on persistent inflammation and metabolic disorders. Methods A pilot study was conducted involving fourteen patients living with HIV-1. The patients were divided into two groups of seven in each group. One group consisted of patients with metabolic syndrome, and the other group included patients without metabolic syndrome. Gut microbiota was characterized using 16 S rRNA gene-targeted sequencing to analyze microbial diversity and composition. Beta diversity and the relative abundance of bacterial taxa were compared between patients with and without metabolic syndrome. Results Patients living with HIV-1 and metabolic syndrome showed significantly altered beta diversity compared to those without metabolic syndrome. A higher relative abundance of Firmicutes and increased proliferation of Proteobacteria were observed in patients with metabolic syndrome. Additionally, a decrease in metabolically beneficial bacteria, such as Bifidobacterium sp., Lactobacillus sp., Akkermansia sp., and Faecalibacterium sp., was noted. Several beneficial bacterial species were associated with participants' metadata, suggesting potential links between gut microbiota and metabolic syndrome. Conclusion This preliminary study highlights that gut microbial balance, rather than the presence of specific bacteria, plays a crucial role in managing metabolic health in patients living with HIV-1. The altered gut microbiota in participants with metabolic syndrome emphasizes the need for further research into the optimal gut microbial structure. Understanding the interaction between gut microbiota changes and the chemical environment in these patients could guide targeted interventions to improve metabolic outcomes.https://doi.org/10.1186/s13098-025-01653-4Gut microbiotaDysbiosisHIVMetabolic syndrome |
| spellingShingle | Joël Martial Diesse Sushama Jadhav Stephen Lacmata Tamekou Gustave Simo Jean Paul Dzoyem Jacob Souopgui Jules-Roger Kuiate Vijay Nema Disturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with HIV-1 and on antiretroviral therapy at Bafoussam Regional Hospital, Cameroon Diabetology & Metabolic Syndrome Gut microbiota Dysbiosis HIV Metabolic syndrome |
| title | Disturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with HIV-1 and on antiretroviral therapy at Bafoussam Regional Hospital, Cameroon |
| title_full | Disturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with HIV-1 and on antiretroviral therapy at Bafoussam Regional Hospital, Cameroon |
| title_fullStr | Disturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with HIV-1 and on antiretroviral therapy at Bafoussam Regional Hospital, Cameroon |
| title_full_unstemmed | Disturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with HIV-1 and on antiretroviral therapy at Bafoussam Regional Hospital, Cameroon |
| title_short | Disturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with HIV-1 and on antiretroviral therapy at Bafoussam Regional Hospital, Cameroon |
| title_sort | disturbances in the gut microbiota potentially associated with metabolic syndrome among patients living with hiv 1 and on antiretroviral therapy at bafoussam regional hospital cameroon |
| topic | Gut microbiota Dysbiosis HIV Metabolic syndrome |
| url | https://doi.org/10.1186/s13098-025-01653-4 |
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