The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality bu...

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Main Authors: Norie Sawada, Petra A Wark, Melissa A Merritt, Shoichiro Tsugane, Heather A Ward, Sabina Rinaldi, Elisabete Weiderpass, Laureen Dartois, Mathilde His, Marie-Christine Boutron-Ruault, Renée Turzanski-Fortner, Rudolf Kaaks, Kim Overvad, María-Luisa Redondo, Noemie Travier, Elena Molina-Portillo, Miren Dorronsoro, Lluis Cirera, Eva Ardanaz, Aurora Perez-Cornago, Antonia Trichopoulou, Pagona Lagiou, Elissavet Valanou, Giovanna Masala, Valeria Pala, Petra Hm Peeters, Yvonne T van der Schouw, Olle Melander, Jonas Manjer, Marisa da Silva, Guri Skeie, Anne Tjønneland, Anja Olsen, Marc J Gunter, Elio Riboli, Amanda J Cross
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0173117&type=printable
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author Norie Sawada
Petra A Wark
Melissa A Merritt
Shoichiro Tsugane
Heather A Ward
Sabina Rinaldi
Elisabete Weiderpass
Laureen Dartois
Mathilde His
Marie-Christine Boutron-Ruault
Renée Turzanski-Fortner
Rudolf Kaaks
Kim Overvad
María-Luisa Redondo
Noemie Travier
Elena Molina-Portillo
Miren Dorronsoro
Lluis Cirera
Eva Ardanaz
Aurora Perez-Cornago
Antonia Trichopoulou
Pagona Lagiou
Elissavet Valanou
Giovanna Masala
Valeria Pala
Petra Hm Peeters
Yvonne T van der Schouw
Olle Melander
Jonas Manjer
Marisa da Silva
Guri Skeie
Anne Tjønneland
Anja Olsen
Marc J Gunter
Elio Riboli
Amanda J Cross
author_facet Norie Sawada
Petra A Wark
Melissa A Merritt
Shoichiro Tsugane
Heather A Ward
Sabina Rinaldi
Elisabete Weiderpass
Laureen Dartois
Mathilde His
Marie-Christine Boutron-Ruault
Renée Turzanski-Fortner
Rudolf Kaaks
Kim Overvad
María-Luisa Redondo
Noemie Travier
Elena Molina-Portillo
Miren Dorronsoro
Lluis Cirera
Eva Ardanaz
Aurora Perez-Cornago
Antonia Trichopoulou
Pagona Lagiou
Elissavet Valanou
Giovanna Masala
Valeria Pala
Petra Hm Peeters
Yvonne T van der Schouw
Olle Melander
Jonas Manjer
Marisa da Silva
Guri Skeie
Anne Tjønneland
Anja Olsen
Marc J Gunter
Elio Riboli
Amanda J Cross
author_sort Norie Sawada
collection DOAJ
description Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in ~253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: HRQ5 vs. Q1 = 1.11, 95%CI = 1.00-1.24; women: HRQ5 vs. Q1 = 1.17, 95%CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: HRQ5 vs. Q1 = 0.63, 95%CI = 0.56-0.71; women: HRQ5 vs. Q1 = 0.81, 95%CI = 0.70-0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: HRQ5 vs. Q1 = 0.64, 95%CI = 0.55-0.75; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.49-0.74) and respiratory disease mortality (men: HRQ5 vs. Q1 = 0.45, 95%CI = 0.28-0.71; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.40-0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.
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spelling doaj-art-1fde3d602f4a4a4c848a7480a8d078fd2025-08-20T02:31:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017311710.1371/journal.pone.0173117The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).Norie SawadaPetra A WarkMelissa A MerrittShoichiro TsuganeHeather A WardSabina RinaldiElisabete WeiderpassLaureen DartoisMathilde HisMarie-Christine Boutron-RuaultRenée Turzanski-FortnerRudolf KaaksKim OvervadMaría-Luisa RedondoNoemie TravierElena Molina-PortilloMiren DorronsoroLluis CireraEva ArdanazAurora Perez-CornagoAntonia TrichopoulouPagona LagiouElissavet ValanouGiovanna MasalaValeria PalaPetra Hm PeetersYvonne T van der SchouwOlle MelanderJonas ManjerMarisa da SilvaGuri SkeieAnne TjønnelandAnja OlsenMarc J GunterElio RiboliAmanda J CrossAdult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in ~253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: HRQ5 vs. Q1 = 1.11, 95%CI = 1.00-1.24; women: HRQ5 vs. Q1 = 1.17, 95%CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: HRQ5 vs. Q1 = 0.63, 95%CI = 0.56-0.71; women: HRQ5 vs. Q1 = 0.81, 95%CI = 0.70-0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: HRQ5 vs. Q1 = 0.64, 95%CI = 0.55-0.75; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.49-0.74) and respiratory disease mortality (men: HRQ5 vs. Q1 = 0.45, 95%CI = 0.28-0.71; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.40-0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0173117&type=printable
spellingShingle Norie Sawada
Petra A Wark
Melissa A Merritt
Shoichiro Tsugane
Heather A Ward
Sabina Rinaldi
Elisabete Weiderpass
Laureen Dartois
Mathilde His
Marie-Christine Boutron-Ruault
Renée Turzanski-Fortner
Rudolf Kaaks
Kim Overvad
María-Luisa Redondo
Noemie Travier
Elena Molina-Portillo
Miren Dorronsoro
Lluis Cirera
Eva Ardanaz
Aurora Perez-Cornago
Antonia Trichopoulou
Pagona Lagiou
Elissavet Valanou
Giovanna Masala
Valeria Pala
Petra Hm Peeters
Yvonne T van der Schouw
Olle Melander
Jonas Manjer
Marisa da Silva
Guri Skeie
Anne Tjønneland
Anja Olsen
Marc J Gunter
Elio Riboli
Amanda J Cross
The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).
PLoS ONE
title The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).
title_full The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).
title_fullStr The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).
title_full_unstemmed The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).
title_short The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC).
title_sort association between adult attained height and sitting height with mortality in the european prospective investigation into cancer and nutrition epic
url https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0173117&type=printable
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