Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus
Aims. This study is aimed at exploring the relation between IL-33 single-nucleotide polymorphisms (SNPs) and the risk of systemic lupus erythematosus (SLE). Methods. SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls. Generalized multifactor dimensionality reducti...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/1547578 |
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| author | Xiaohua Zhu Lin Xie Haihong Qin Jun Liang Yongsheng Yang Jinhua Xu Tiejun Zhang |
| author_facet | Xiaohua Zhu Lin Xie Haihong Qin Jun Liang Yongsheng Yang Jinhua Xu Tiejun Zhang |
| author_sort | Xiaohua Zhu |
| collection | DOAJ |
| description | Aims. This study is aimed at exploring the relation between IL-33 single-nucleotide polymorphisms (SNPs) and the risk of systemic lupus erythematosus (SLE). Methods. SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls. Generalized multifactor dimensionality reduction (GMDR) was adopted to screen the preferable interaction between IL-33 SNPs and current smoking. Results. Logistic regression analysis based on the fundamental data of age, gender, BMI, current smoking, and alcohol drinking showed that both rs1929992-G and rs1891385-C alleles were correlated with an increasing risk of SLE, the ORs (95% CI) of which were 1.62 (1.21-2.05) and 1.64 (1.22-2.10), respectively. One two-locus model (rs1929992×current smoking) had a testing accuracy of 60.11% (P=0.0010). Through an overall multidimensional model, optimum cross-validation consistency was obtained. The analysis indicated that current smoking status influenced the SLE risk depending on the genotypes at rs1929992. Pairwise LD analysis indicated that haplotype rs1929992G-rs7044343T was statistically related to the elevating risk of SLE (P<0.05). Those subjects with the G-T haplotype had a higher SLE risk than those with other haplotypes, after correction with factors, including gender, alcohol drinking, age, BMI, and current smoking. Conclusions. The rs1929992-G and rs1891385-C allele, interaction between the rs1929992 gene and current smoking, and haplotype rs1929992G-rs7044343T were all risk factors of SLE. |
| format | Article |
| id | doaj-art-1fdc6bb77b184b74bb352de2127c78f0 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-1fdc6bb77b184b74bb352de2127c78f02025-08-20T02:03:47ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/15475781547578Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus ErythematosusXiaohua Zhu0Lin Xie1Haihong Qin2Jun Liang3Yongsheng Yang4Jinhua Xu5Tiejun Zhang6Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Fudan University, Shanghai 200040, ChinaAims. This study is aimed at exploring the relation between IL-33 single-nucleotide polymorphisms (SNPs) and the risk of systemic lupus erythematosus (SLE). Methods. SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls. Generalized multifactor dimensionality reduction (GMDR) was adopted to screen the preferable interaction between IL-33 SNPs and current smoking. Results. Logistic regression analysis based on the fundamental data of age, gender, BMI, current smoking, and alcohol drinking showed that both rs1929992-G and rs1891385-C alleles were correlated with an increasing risk of SLE, the ORs (95% CI) of which were 1.62 (1.21-2.05) and 1.64 (1.22-2.10), respectively. One two-locus model (rs1929992×current smoking) had a testing accuracy of 60.11% (P=0.0010). Through an overall multidimensional model, optimum cross-validation consistency was obtained. The analysis indicated that current smoking status influenced the SLE risk depending on the genotypes at rs1929992. Pairwise LD analysis indicated that haplotype rs1929992G-rs7044343T was statistically related to the elevating risk of SLE (P<0.05). Those subjects with the G-T haplotype had a higher SLE risk than those with other haplotypes, after correction with factors, including gender, alcohol drinking, age, BMI, and current smoking. Conclusions. The rs1929992-G and rs1891385-C allele, interaction between the rs1929992 gene and current smoking, and haplotype rs1929992G-rs7044343T were all risk factors of SLE.http://dx.doi.org/10.1155/2019/1547578 |
| spellingShingle | Xiaohua Zhu Lin Xie Haihong Qin Jun Liang Yongsheng Yang Jinhua Xu Tiejun Zhang Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus Journal of Immunology Research |
| title | Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus |
| title_full | Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus |
| title_fullStr | Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus |
| title_full_unstemmed | Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus |
| title_short | Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus |
| title_sort | interaction between il 33 gene polymorphisms and current smoking with susceptibility to systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2019/1547578 |
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