The role of oxidized lipid species in insulin resistance and NASH in children
During the last two decades, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common hepatic disease in pediatrics, mainly owing to the rising prevalence of pediatric obesity. Epidemiological studies have shown that the progressive increase in NAFLD prevalence is associated not only...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1019204/full |
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| author | Nicola Santoro Nicola Santoro Nicola Santoro Ariel E. Feldstein Ariel E. Feldstein |
| author_facet | Nicola Santoro Nicola Santoro Nicola Santoro Ariel E. Feldstein Ariel E. Feldstein |
| author_sort | Nicola Santoro |
| collection | DOAJ |
| description | During the last two decades, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common hepatic disease in pediatrics, mainly owing to the rising prevalence of pediatric obesity. Epidemiological studies have shown that the progressive increase in NAFLD prevalence is associated not only with obesity but also with changes in dietary habits experienced by all age groups, characterized by the increased intake of added sugars and certain fatty acids. In this review article, we focus on the effect of oxidized fatty acids deriving from linoleic acid and arachidonic acid on the pathogenesis and progression of NAFLD in youth. |
| format | Article |
| id | doaj-art-1fdc410a5ce045acbb05793946155639 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-1fdc410a5ce045acbb057939461556392025-08-20T02:37:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-10-011310.3389/fendo.2022.10192041019204The role of oxidized lipid species in insulin resistance and NASH in childrenNicola Santoro0Nicola Santoro1Nicola Santoro2Ariel E. Feldstein3Ariel E. Feldstein4Department of Pediatrics, Kansas Medical Center, Kansas City, KS, United StatesDepartment of Medicine and Health Sciences, “V.Tiberio” University of Molise, Campobasso, ItalyDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Pediatrics, University of California San Diego, La Jolla, CA, United StatesGlobal Drug Discovery, Novo Nordisk, Copenhagen, DenmarkDuring the last two decades, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common hepatic disease in pediatrics, mainly owing to the rising prevalence of pediatric obesity. Epidemiological studies have shown that the progressive increase in NAFLD prevalence is associated not only with obesity but also with changes in dietary habits experienced by all age groups, characterized by the increased intake of added sugars and certain fatty acids. In this review article, we focus on the effect of oxidized fatty acids deriving from linoleic acid and arachidonic acid on the pathogenesis and progression of NAFLD in youth.https://www.frontiersin.org/articles/10.3389/fendo.2022.1019204/fulllipidsPUFA (polyunsaturated fatty acids)NAFLD (nonalcoholic fatty liver disease)diabeteschildren |
| spellingShingle | Nicola Santoro Nicola Santoro Nicola Santoro Ariel E. Feldstein Ariel E. Feldstein The role of oxidized lipid species in insulin resistance and NASH in children Frontiers in Endocrinology lipids PUFA (polyunsaturated fatty acids) NAFLD (nonalcoholic fatty liver disease) diabetes children |
| title | The role of oxidized lipid species in insulin resistance and NASH in children |
| title_full | The role of oxidized lipid species in insulin resistance and NASH in children |
| title_fullStr | The role of oxidized lipid species in insulin resistance and NASH in children |
| title_full_unstemmed | The role of oxidized lipid species in insulin resistance and NASH in children |
| title_short | The role of oxidized lipid species in insulin resistance and NASH in children |
| title_sort | role of oxidized lipid species in insulin resistance and nash in children |
| topic | lipids PUFA (polyunsaturated fatty acids) NAFLD (nonalcoholic fatty liver disease) diabetes children |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1019204/full |
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