Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years
Knee osteoarthritis is a major cause of disability worldwide. Newer modalities of treatment with less morbidity, such as intra-articular injection of microfragmented fat (MFAT), are showing promise. We report on our novel observation that women show a greater improvement in pain and function to MFAT...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/6648437 |
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| _version_ | 1849308006935691264 |
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| author | Tiffanie-Marie Borg Nima Heidari Ali Noorani Mark Slevin Angela Cullen Stefano Olgiati Alberto Zerbi Alessandro Danovi Adrian Wilson |
| author_facet | Tiffanie-Marie Borg Nima Heidari Ali Noorani Mark Slevin Angela Cullen Stefano Olgiati Alberto Zerbi Alessandro Danovi Adrian Wilson |
| author_sort | Tiffanie-Marie Borg |
| collection | DOAJ |
| description | Knee osteoarthritis is a major cause of disability worldwide. Newer modalities of treatment with less morbidity, such as intra-articular injection of microfragmented fat (MFAT), are showing promise. We report on our novel observation that women show a greater improvement in pain and function to MFAT than men. Traditionally, women have been underrepresented in studies and studies with both sexes regularly fail to analyze the results by sex. To mitigate for this bias and quantify it, we describe a technique using reproducible statistical analysis and replicable results with Open Access statistical software R to calculate the magnitude of this difference. Genetic, hormonal, environmental, and age factors play a role in our observed difference between the sexes. There is a need for further studies to identify the molecular basis for this difference and be able to utilize it to improve outcome for both women and men. |
| format | Article |
| id | doaj-art-1fdb9565cc2b4334a577593ea5b340d0 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1fdb9565cc2b4334a577593ea5b340d02025-08-20T03:54:34ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/66484376648437Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two YearsTiffanie-Marie Borg0Nima Heidari1Ali Noorani2Mark Slevin3Angela Cullen4Stefano Olgiati5Alberto Zerbi6Alessandro Danovi7Adrian Wilson8Academic Plastic Surgery Group, Barts and the London School of Medicine, UKThe Regenerative Clinic, 18-22 Queen Anne Street, London, UKThe Regenerative Clinic, 18-22 Queen Anne Street, London, UKThe Regenerative Clinic, 18-22 Queen Anne Street, London, UKThe Regenerative Clinic, 18-22 Queen Anne Street, London, UKnextAI, London, UKUniversity of Milano, Department of Radiology, 20100 Milano, ItalyDepartment of Quantitative Methods, University of Bergamo, 24129 Bergamo, ItalyThe Regenerative Clinic, 18-22 Queen Anne Street, London, UKKnee osteoarthritis is a major cause of disability worldwide. Newer modalities of treatment with less morbidity, such as intra-articular injection of microfragmented fat (MFAT), are showing promise. We report on our novel observation that women show a greater improvement in pain and function to MFAT than men. Traditionally, women have been underrepresented in studies and studies with both sexes regularly fail to analyze the results by sex. To mitigate for this bias and quantify it, we describe a technique using reproducible statistical analysis and replicable results with Open Access statistical software R to calculate the magnitude of this difference. Genetic, hormonal, environmental, and age factors play a role in our observed difference between the sexes. There is a need for further studies to identify the molecular basis for this difference and be able to utilize it to improve outcome for both women and men.http://dx.doi.org/10.1155/2021/6648437 |
| spellingShingle | Tiffanie-Marie Borg Nima Heidari Ali Noorani Mark Slevin Angela Cullen Stefano Olgiati Alberto Zerbi Alessandro Danovi Adrian Wilson Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years Stem Cells International |
| title | Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years |
| title_full | Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years |
| title_fullStr | Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years |
| title_full_unstemmed | Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years |
| title_short | Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years |
| title_sort | gender specific response in pain and function to biologic treatment of knee osteoarthritis a gender bias mitigated observational intention to treat study at two years |
| url | http://dx.doi.org/10.1155/2021/6648437 |
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