In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism
Preeclampsia (PE) may affect the risk for future cardiovascular disease. Haptoglobin (Hp), an acute phase protein with functional genetic polymorphism, synthesized in the hepatocyte and in many peripheral tissues secondary of oxidative stress of PE, may modulate that risk through the antioxidant, an...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2014/361727 |
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| author | Andreia Matos Alda Pereira da Silva Maria Clara Bicho Conceição Afonso Maria José Areias Irene Rebelo Manuel Bicho |
| author_facet | Andreia Matos Alda Pereira da Silva Maria Clara Bicho Conceição Afonso Maria José Areias Irene Rebelo Manuel Bicho |
| author_sort | Andreia Matos |
| collection | DOAJ |
| description | Preeclampsia (PE) may affect the risk for future cardiovascular disease. Haptoglobin (Hp), an acute phase protein with functional genetic polymorphism, synthesized in the hepatocyte and in many peripheral tissues secondary of oxidative stress of PE, may modulate that risk through the antioxidant, angiogenic, and anti-inflammatory differential effects of their genotypes. We performed a prospective study in 352 women aged 35±5.48 years, which 165 had previous PE, 2 to 16 years ago. We studied demographic, anthropometric, and haemodynamic biomarkers such as C-reactive protein (CRP), myeloperoxidase (MPO), and nitric oxide metabolites (total and nitrites), and others associated with liver function (AST and ALT) and lipid profile (total LDL and cholesterol HDL, non-HDL, and apolipoproteins A and B). Finally, we study the influence of Hp genetic polymorphism on all these biomarkers and as a predisposing factor for PE and its remote cardiovascular disease prognosis. Previously preeclamptic women either hypertensive or normotensive presented significant differences in those risk biomarkers (MPO, nitrites, and ALT), whose variation may be modulated by Hp 1/2 functional genetic polymorphism. The history of PE may be relevant, in association with these biomarkers to the cardiovascular risk in premenopausal women. |
| format | Article |
| id | doaj-art-1fd9033691f84065aa308815455791d3 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-1fd9033691f84065aa308815455791d32025-02-03T01:07:45ZengWileyObstetrics and Gynecology International1687-95891687-95972014-01-01201410.1155/2014/361727361727In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin PolymorphismAndreia Matos0Alda Pereira da Silva1Maria Clara Bicho2Conceição Afonso3Maria José Areias4Irene Rebelo5Manuel Bicho6Genetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, PortugalGenetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, PortugalGenetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, PortugalGenetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, PortugalJúlio Diniz Maternity, Maria Pia Hospital, 4050-371 Porto, PortugalDepartment of Biochemistry, Faculty of Pharmacy and Institute for Molecular and Cell Biology, University of Porto, 4050-313 Porto, PortugalGenetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, PortugalPreeclampsia (PE) may affect the risk for future cardiovascular disease. Haptoglobin (Hp), an acute phase protein with functional genetic polymorphism, synthesized in the hepatocyte and in many peripheral tissues secondary of oxidative stress of PE, may modulate that risk through the antioxidant, angiogenic, and anti-inflammatory differential effects of their genotypes. We performed a prospective study in 352 women aged 35±5.48 years, which 165 had previous PE, 2 to 16 years ago. We studied demographic, anthropometric, and haemodynamic biomarkers such as C-reactive protein (CRP), myeloperoxidase (MPO), and nitric oxide metabolites (total and nitrites), and others associated with liver function (AST and ALT) and lipid profile (total LDL and cholesterol HDL, non-HDL, and apolipoproteins A and B). Finally, we study the influence of Hp genetic polymorphism on all these biomarkers and as a predisposing factor for PE and its remote cardiovascular disease prognosis. Previously preeclamptic women either hypertensive or normotensive presented significant differences in those risk biomarkers (MPO, nitrites, and ALT), whose variation may be modulated by Hp 1/2 functional genetic polymorphism. The history of PE may be relevant, in association with these biomarkers to the cardiovascular risk in premenopausal women.http://dx.doi.org/10.1155/2014/361727 |
| spellingShingle | Andreia Matos Alda Pereira da Silva Maria Clara Bicho Conceição Afonso Maria José Areias Irene Rebelo Manuel Bicho In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism Obstetrics and Gynecology International |
| title | In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism |
| title_full | In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism |
| title_fullStr | In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism |
| title_full_unstemmed | In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism |
| title_short | In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism |
| title_sort | in women with previous pregnancy hypertension levels of cardiovascular risk biomarkers may be modulated by haptoglobin polymorphism |
| url | http://dx.doi.org/10.1155/2014/361727 |
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