Effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors: a randomized controlled trial
PurposeTo investigate the effects of lavender essential oil (LEO) on postoperative sleep quality and perioperative neurocognitive disorders (PNDs) in patients with intracranial tumors.Patients and methodsThis study was a randomized controlled trial in which all patients were randomly assigned to eit...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1584998/full |
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| author | Yang Liu Yanmei Dong Yanmei Dong Xin Wang Yeqin Huang Yeqin Huang Fan Wu Fei Xia Fei Xia Hongtong Bai Hongtong Bai Hui Li Hui Li Lei Shi Lei Shi Baoguo Wang |
| author_facet | Yang Liu Yanmei Dong Yanmei Dong Xin Wang Yeqin Huang Yeqin Huang Fan Wu Fei Xia Fei Xia Hongtong Bai Hongtong Bai Hui Li Hui Li Lei Shi Lei Shi Baoguo Wang |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | PurposeTo investigate the effects of lavender essential oil (LEO) on postoperative sleep quality and perioperative neurocognitive disorders (PNDs) in patients with intracranial tumors.Patients and methodsThis study was a randomized controlled trial in which all patients were randomly assigned to either the control group, which received no intervention, or the experimental group, which received LEO. Postoperative sleep quality was assessed using a dedicated sleep monitor. The PNDs were evaluated by the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) and the Mini-Mental State Examination (MMSE), using education-adjusted cutoffs recommended by the latest Chinese Dementia Guidelines (2023).ResultsCompared with the control group, the total sleep duration and the deep sleep duration were significantly longer in the experimental group only on the fourth postoperative day (418.48 ± 21.95 vs. 389.57 ± 49.29, P = 0.019; 95.10 ± 19.98 vs. 66.86 ± 32.69, P = 0.002). The experimental group exhibited significantly shorter sleep latency compared with the control group (13.24 ± 8.46 vs. 28.62 ± 19.86; p = 0.002). Additionally, the apnea-hypopnea index and frequency of awakenings were lower in the experimental group (14.05 ± 9.85 vs. 21.00 ± 10.78; p = 0.035; 2.67 ± 1.32 vs. 5.05 ± 2.97; p = 0.002). The duration of postoperative delirium was shorter in the experimental group compared with the control group (2.00 ± 0.82 vs. 3.80 ± 1.30; p = 0.048). On the seventh postoperative day, participants in the experimental group had lower anxiety scores than those in the control group (3.38 ± 2.27 vs. 6.14 ± 5.43; p = 0.038).ConclusionLEO inhalation aromatherapy could effectively improve postoperative sleep quality, particularly on the fourth postoperative day. It also positively impacted anxiety and reduced the duration of postoperative delirium.Clinical Trial Registrationhttps://www.chictr.org.cn/index.html, identifier ChiCTR2300073091. |
| format | Article |
| id | doaj-art-1fd6296465834ba9aa4eaf08f32e9518 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-1fd6296465834ba9aa4eaf08f32e95182025-08-20T03:00:25ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-08-011610.3389/fphar.2025.15849981584998Effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors: a randomized controlled trialYang Liu0Yanmei Dong1Yanmei Dong2Xin Wang3Yeqin Huang4Yeqin Huang5Fan Wu6Fei Xia7Fei Xia8Hongtong Bai9Hongtong Bai10Hui Li11Hui Li12Lei Shi13Lei Shi14Baoguo Wang15Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijin, ChinaState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, ChinaChina National Botanical Garden, Beijing, ChinaDepartment of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijin, ChinaState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, ChinaDepartment of Chemistry “G. Ciamician”, University of Bologna, Bologna, ItalyDepartment of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijin, ChinaState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, ChinaChina National Botanical Garden, Beijing, ChinaState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, ChinaChina National Botanical Garden, Beijing, ChinaState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, ChinaChina National Botanical Garden, Beijing, ChinaState Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, Beijing, ChinaChina National Botanical Garden, Beijing, ChinaDepartment of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijin, ChinaPurposeTo investigate the effects of lavender essential oil (LEO) on postoperative sleep quality and perioperative neurocognitive disorders (PNDs) in patients with intracranial tumors.Patients and methodsThis study was a randomized controlled trial in which all patients were randomly assigned to either the control group, which received no intervention, or the experimental group, which received LEO. Postoperative sleep quality was assessed using a dedicated sleep monitor. The PNDs were evaluated by the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) and the Mini-Mental State Examination (MMSE), using education-adjusted cutoffs recommended by the latest Chinese Dementia Guidelines (2023).ResultsCompared with the control group, the total sleep duration and the deep sleep duration were significantly longer in the experimental group only on the fourth postoperative day (418.48 ± 21.95 vs. 389.57 ± 49.29, P = 0.019; 95.10 ± 19.98 vs. 66.86 ± 32.69, P = 0.002). The experimental group exhibited significantly shorter sleep latency compared with the control group (13.24 ± 8.46 vs. 28.62 ± 19.86; p = 0.002). Additionally, the apnea-hypopnea index and frequency of awakenings were lower in the experimental group (14.05 ± 9.85 vs. 21.00 ± 10.78; p = 0.035; 2.67 ± 1.32 vs. 5.05 ± 2.97; p = 0.002). The duration of postoperative delirium was shorter in the experimental group compared with the control group (2.00 ± 0.82 vs. 3.80 ± 1.30; p = 0.048). On the seventh postoperative day, participants in the experimental group had lower anxiety scores than those in the control group (3.38 ± 2.27 vs. 6.14 ± 5.43; p = 0.038).ConclusionLEO inhalation aromatherapy could effectively improve postoperative sleep quality, particularly on the fourth postoperative day. It also positively impacted anxiety and reduced the duration of postoperative delirium.Clinical Trial Registrationhttps://www.chictr.org.cn/index.html, identifier ChiCTR2300073091.https://www.frontiersin.org/articles/10.3389/fphar.2025.1584998/fulllavender essential oilintracranial tumorsleep qualityperioperative neurocognitive disordersanxiety |
| spellingShingle | Yang Liu Yanmei Dong Yanmei Dong Xin Wang Yeqin Huang Yeqin Huang Fan Wu Fei Xia Fei Xia Hongtong Bai Hongtong Bai Hui Li Hui Li Lei Shi Lei Shi Baoguo Wang Effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors: a randomized controlled trial Frontiers in Pharmacology lavender essential oil intracranial tumor sleep quality perioperative neurocognitive disorders anxiety |
| title | Effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors: a randomized controlled trial |
| title_full | Effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors: a randomized controlled trial |
| title_fullStr | Effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors: a randomized controlled trial |
| title_full_unstemmed | Effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors: a randomized controlled trial |
| title_short | Effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors: a randomized controlled trial |
| title_sort | effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors a randomized controlled trial |
| topic | lavender essential oil intracranial tumor sleep quality perioperative neurocognitive disorders anxiety |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1584998/full |
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