Ferroptosis in cancer: revealing the multifaceted functions of mitochondria

Ferroptosis in cancer: revealing the multifaceted functions of mitochondria

Abstract Ferroptosis is a programmed cell death characterized by iron-dependent lipid peroxidation, which is regulated by various cellular metabolic and signaling pathways. The main regulatory mechanisms of intracellular ferroptosis include the GSH-GPX4 pathway, the FSP1-CoQ10 pathway, the GCH1-BH4...

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Main Authors: Xinyi Ding, Lei Cui, Yanjun Mi, Jiachun Hu, Zheyou Cai, Qing Tang, Linhao Yang, Zhuang Yang, Qingbing Wang, Hongsheng Li, Benxin Hou, Quentin Liu, Zhengzhi Zou, Yibing Chen
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cellular and Molecular Life Sciences
Subjects:
Ferroptosis
Mitochondria
Tumor
Metabolism
Chemoresistance
Online Access:https://doi.org/10.1007/s00018-025-05812-8
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