Analysis of the mechanism of Erchen decoction in treating chronic bronchitis based on network pharmacology and molecular docking
[Abstract]: Objective: In this study, we used network pharmacology to explore the main targets and signaling pathways of Erchen decoction in the treatment of chronic bronchitis. Methods: The effective active ingredients of Erchen decoction were screened through the traditional Chinese medicine syst...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2021-06-01
|
| Series: | Journal of Holistic Integrative Pharmacy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2707368823000134 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850194158729297920 |
|---|---|
| author | Yanshan HE Rui WANG Jinlian ZHU Yingjia DENG Yafang DENG Yuanning ZENG Qiuhong WANG |
| author_facet | Yanshan HE Rui WANG Jinlian ZHU Yingjia DENG Yafang DENG Yuanning ZENG Qiuhong WANG |
| author_sort | Yanshan HE |
| collection | DOAJ |
| description | [Abstract]: Objective: In this study, we used network pharmacology to explore the main targets and signaling pathways of Erchen decoction in the treatment of chronic bronchitis. Methods: The effective active ingredients of Erchen decoction were screened through the traditional Chinese medicine systems pharmacology database and analysis platform, and the relevant protein targets of chronic bronchitis were retrieved through the GeneCards database using the STRING platform to construct a protein–protein interaction network. Cytoscape software was used to construct drug-component-target network diagrams. Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis were performed on the intersection target genes. Results and conclusion: After database analysis, 256 active ingredients in Erchen decoction were screened as well as 110 targets related to chronic bronchitis and 188 related signaling pathways. Erchen decoction was found to play a potential role in the treatment of chronic bronchitis by regulating inflammation, immunity, cough, and phlegm and other multiple targets and multiple pathways. |
| format | Article |
| id | doaj-art-1fd0a25f60f9482c8a85909c7309cfd3 |
| institution | OA Journals |
| issn | 2707-3688 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Holistic Integrative Pharmacy |
| spelling | doaj-art-1fd0a25f60f9482c8a85909c7309cfd32025-08-20T02:14:03ZengKeAi Communications Co., Ltd.Journal of Holistic Integrative Pharmacy2707-36882021-06-01229611110.1016/S2707-3688(23)00013-4Analysis of the mechanism of Erchen decoction in treating chronic bronchitis based on network pharmacology and molecular dockingYanshan HE0Rui WANG1Jinlian ZHU2Yingjia DENG3Yafang DENG4Yuanning ZENG5Qiuhong WANG6School of TCM, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaKey Laboratory of Basic and Applied Research of Northern Medicine, Ministry of Education, Heilongjiang Key Laboratory of Pharmacodynamic Material Basis of Traditional Chinese Medicine (TCM) and Natural Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaSchool of TCM, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of TCM, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of TCM, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of TCM, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of TCM, Guangdong Pharmaceutical University, Guangzhou 510006, China; [Corresponding author][Abstract]: Objective: In this study, we used network pharmacology to explore the main targets and signaling pathways of Erchen decoction in the treatment of chronic bronchitis. Methods: The effective active ingredients of Erchen decoction were screened through the traditional Chinese medicine systems pharmacology database and analysis platform, and the relevant protein targets of chronic bronchitis were retrieved through the GeneCards database using the STRING platform to construct a protein–protein interaction network. Cytoscape software was used to construct drug-component-target network diagrams. Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis were performed on the intersection target genes. Results and conclusion: After database analysis, 256 active ingredients in Erchen decoction were screened as well as 110 targets related to chronic bronchitis and 188 related signaling pathways. Erchen decoction was found to play a potential role in the treatment of chronic bronchitis by regulating inflammation, immunity, cough, and phlegm and other multiple targets and multiple pathways.http://www.sciencedirect.com/science/article/pii/S2707368823000134Erchen decoctionChronic bronchitisNetwork pharmacologyActive ingredientSignaling pathway |
| spellingShingle | Yanshan HE Rui WANG Jinlian ZHU Yingjia DENG Yafang DENG Yuanning ZENG Qiuhong WANG Analysis of the mechanism of Erchen decoction in treating chronic bronchitis based on network pharmacology and molecular docking Journal of Holistic Integrative Pharmacy Erchen decoction Chronic bronchitis Network pharmacology Active ingredient Signaling pathway |
| title | Analysis of the mechanism of Erchen decoction in treating chronic bronchitis based on network pharmacology and molecular docking |
| title_full | Analysis of the mechanism of Erchen decoction in treating chronic bronchitis based on network pharmacology and molecular docking |
| title_fullStr | Analysis of the mechanism of Erchen decoction in treating chronic bronchitis based on network pharmacology and molecular docking |
| title_full_unstemmed | Analysis of the mechanism of Erchen decoction in treating chronic bronchitis based on network pharmacology and molecular docking |
| title_short | Analysis of the mechanism of Erchen decoction in treating chronic bronchitis based on network pharmacology and molecular docking |
| title_sort | analysis of the mechanism of erchen decoction in treating chronic bronchitis based on network pharmacology and molecular docking |
| topic | Erchen decoction Chronic bronchitis Network pharmacology Active ingredient Signaling pathway |
| url | http://www.sciencedirect.com/science/article/pii/S2707368823000134 |
| work_keys_str_mv | AT yanshanhe analysisofthemechanismoferchendecoctionintreatingchronicbronchitisbasedonnetworkpharmacologyandmoleculardocking AT ruiwang analysisofthemechanismoferchendecoctionintreatingchronicbronchitisbasedonnetworkpharmacologyandmoleculardocking AT jinlianzhu analysisofthemechanismoferchendecoctionintreatingchronicbronchitisbasedonnetworkpharmacologyandmoleculardocking AT yingjiadeng analysisofthemechanismoferchendecoctionintreatingchronicbronchitisbasedonnetworkpharmacologyandmoleculardocking AT yafangdeng analysisofthemechanismoferchendecoctionintreatingchronicbronchitisbasedonnetworkpharmacologyandmoleculardocking AT yuanningzeng analysisofthemechanismoferchendecoctionintreatingchronicbronchitisbasedonnetworkpharmacologyandmoleculardocking AT qiuhongwang analysisofthemechanismoferchendecoctionintreatingchronicbronchitisbasedonnetworkpharmacologyandmoleculardocking |