Takotsubo Cardiomyopathy and 5-Fluorouracil: Getting to the Heart of the Matter
Takotsubo cardiomyopathy is a rare but increasingly recognized phenomenon, which can occur as a side-effect of chemotherapeutic agents, in particular, the antimetabolite 5-fluorouracil. We describe a case of delayed Takotsubo cardiomyopathy after 3 weeks of adjuvant 5-fluorouracil for resected recta...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/206765 |
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| author | Stephanie Hui-Su Lim Sharon Mary Wilson Arnagretta Hunter Jane Hill Philip Beale |
| author_facet | Stephanie Hui-Su Lim Sharon Mary Wilson Arnagretta Hunter Jane Hill Philip Beale |
| author_sort | Stephanie Hui-Su Lim |
| collection | DOAJ |
| description | Takotsubo cardiomyopathy is a rare but increasingly recognized phenomenon, which can occur as a side-effect of chemotherapeutic agents, in particular, the antimetabolite 5-fluorouracil. We describe a case of delayed Takotsubo cardiomyopathy after 3 weeks of adjuvant 5-fluorouracil for resected rectal adenocarcinoma in a 66-year-old female, supported by angiographic, electrocardiographic, and echocardiographic features. As a complication, she developed an apical mural thrombus with subsequent cerebral thromboembolic events and was successfully anticoagulated to make a full recovery. We present a review of the literature on Takotsubo cardiomyopathy secondary to 5-fluorouracil and the rare occurrence of thromboembolic complications. As this is a significant clinical phenomenon which involves a multispeciality approach to management, oncologists and cardiologists need to recognize it as a potential toxicity of a widely administered chemotherapeutic drug. |
| format | Article |
| id | doaj-art-1fca96e0b6404aff907fcad392a135ed |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-1fca96e0b6404aff907fcad392a135ed2025-08-20T03:54:36ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/206765206765Takotsubo Cardiomyopathy and 5-Fluorouracil: Getting to the Heart of the MatterStephanie Hui-Su Lim0Sharon Mary Wilson1Arnagretta Hunter2Jane Hill3Philip Beale4Department of Medical Oncology, Liverpool Hospital, Elizabeth Street, Liverpool, NSW 2170, AustraliaDepartment of Cardiology, St George Hospital, Kogarah, NSW 2217, AustraliaDepartment of Cardiology, Wagga Wagga Base Hospital, Wagga Wagga, NSW 2650, AustraliaRiverina Cancer Care Centre, Wagga Wagga, NSW 2650, AustraliaConcord Repatriation General Hospital, Concord West, NSW 2138, AustraliaTakotsubo cardiomyopathy is a rare but increasingly recognized phenomenon, which can occur as a side-effect of chemotherapeutic agents, in particular, the antimetabolite 5-fluorouracil. We describe a case of delayed Takotsubo cardiomyopathy after 3 weeks of adjuvant 5-fluorouracil for resected rectal adenocarcinoma in a 66-year-old female, supported by angiographic, electrocardiographic, and echocardiographic features. As a complication, she developed an apical mural thrombus with subsequent cerebral thromboembolic events and was successfully anticoagulated to make a full recovery. We present a review of the literature on Takotsubo cardiomyopathy secondary to 5-fluorouracil and the rare occurrence of thromboembolic complications. As this is a significant clinical phenomenon which involves a multispeciality approach to management, oncologists and cardiologists need to recognize it as a potential toxicity of a widely administered chemotherapeutic drug.http://dx.doi.org/10.1155/2013/206765 |
| spellingShingle | Stephanie Hui-Su Lim Sharon Mary Wilson Arnagretta Hunter Jane Hill Philip Beale Takotsubo Cardiomyopathy and 5-Fluorouracil: Getting to the Heart of the Matter Case Reports in Oncological Medicine |
| title | Takotsubo Cardiomyopathy and 5-Fluorouracil: Getting to the Heart of the Matter |
| title_full | Takotsubo Cardiomyopathy and 5-Fluorouracil: Getting to the Heart of the Matter |
| title_fullStr | Takotsubo Cardiomyopathy and 5-Fluorouracil: Getting to the Heart of the Matter |
| title_full_unstemmed | Takotsubo Cardiomyopathy and 5-Fluorouracil: Getting to the Heart of the Matter |
| title_short | Takotsubo Cardiomyopathy and 5-Fluorouracil: Getting to the Heart of the Matter |
| title_sort | takotsubo cardiomyopathy and 5 fluorouracil getting to the heart of the matter |
| url | http://dx.doi.org/10.1155/2013/206765 |
| work_keys_str_mv | AT stephaniehuisulim takotsubocardiomyopathyand5fluorouracilgettingtotheheartofthematter AT sharonmarywilson takotsubocardiomyopathyand5fluorouracilgettingtotheheartofthematter AT arnagrettahunter takotsubocardiomyopathyand5fluorouracilgettingtotheheartofthematter AT janehill takotsubocardiomyopathyand5fluorouracilgettingtotheheartofthematter AT philipbeale takotsubocardiomyopathyand5fluorouracilgettingtotheheartofthematter |