A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease
Dementia is a debilitating and life-altering disease which leads to both memory impairment and decline of normal executive functioning. While causes of dementia are numerous and varied, the leading cause among patients 60 years and older is Alzheimer’s disease. The gold standard for Alzheimer’s diag...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-2009-0225 |
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| _version_ | 1849308001045839872 |
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| author | Jason Appel Elizabeth Potter Qian Shen Gustavo Pantol Maria T. Greig David Loewenstein Ranjan Duara |
| author_facet | Jason Appel Elizabeth Potter Qian Shen Gustavo Pantol Maria T. Greig David Loewenstein Ranjan Duara |
| author_sort | Jason Appel |
| collection | DOAJ |
| description | Dementia is a debilitating and life-altering disease which leads to both memory impairment and decline of normal executive functioning. While causes of dementia are numerous and varied, the leading cause among patients 60 years and older is Alzheimer’s disease. The gold standard for Alzheimer’s diagnosis remains histological identification of amyloid plaques and neurofibrillary tangles within the medial temporal lobe, more specifically the entorhinal cortex and hippocampus. Although no definitive cure for Alzheimer's disease currently exists, there are treatments targeted at preserving cognition and memory while delaying continued loss of function. Alzheimer's disease exists along a spectrum of cognitive decline and is often preceded by Mild Cognitive Impairment (MCI). Patients with MCI demonstrate memory loss and cognitive impairment while still continuing normal activities of daily living, and are considered to be at increased risk for developing Alzheimer's Dementia. Identifying patients with prodromal states of Alzheimer's dementia such as MCI may allow initiation of appropriate treatment planning and delay of cognitive decline. Therefore, the need for a non-invasive early biomarker for the detection of Alzheimer's disease has never been greater. Multiple neuroimaging methods utilizing visual rating scales, volumetric measurements, and automated methods have been developed to identify, quantify, and track anatomic sequelae of Alzheimer’s Disease. |
| format | Article |
| id | doaj-art-1fca45cb0e984ae688f224640dfad3ca |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-1fca45cb0e984ae688f224640dfad3ca2025-08-20T03:54:36ZengWileyBehavioural Neurology0953-41801875-85842009-01-01211-2131910.3233/BEN-2009-0225A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s DiseaseJason Appel0Elizabeth Potter1Qian Shen2Gustavo Pantol3Maria T. Greig4David Loewenstein5Ranjan Duara6Mount Sinai Medical Center, Wien Center, Miami Beach, FL, USAMount Sinai Medical Center, Wien Center, Miami Beach, FL, USAMount Sinai Medical Center, Wien Center, Miami Beach, FL, USAMount Sinai Medical Center, Wien Center, Miami Beach, FL, USAMount Sinai Medical Center, Wien Center, Miami Beach, FL, USAMount Sinai Medical Center, Wien Center, Miami Beach, FL, USAMount Sinai Medical Center, Wien Center, Miami Beach, FL, USADementia is a debilitating and life-altering disease which leads to both memory impairment and decline of normal executive functioning. While causes of dementia are numerous and varied, the leading cause among patients 60 years and older is Alzheimer’s disease. The gold standard for Alzheimer’s diagnosis remains histological identification of amyloid plaques and neurofibrillary tangles within the medial temporal lobe, more specifically the entorhinal cortex and hippocampus. Although no definitive cure for Alzheimer's disease currently exists, there are treatments targeted at preserving cognition and memory while delaying continued loss of function. Alzheimer's disease exists along a spectrum of cognitive decline and is often preceded by Mild Cognitive Impairment (MCI). Patients with MCI demonstrate memory loss and cognitive impairment while still continuing normal activities of daily living, and are considered to be at increased risk for developing Alzheimer's Dementia. Identifying patients with prodromal states of Alzheimer's dementia such as MCI may allow initiation of appropriate treatment planning and delay of cognitive decline. Therefore, the need for a non-invasive early biomarker for the detection of Alzheimer's disease has never been greater. Multiple neuroimaging methods utilizing visual rating scales, volumetric measurements, and automated methods have been developed to identify, quantify, and track anatomic sequelae of Alzheimer’s Disease.http://dx.doi.org/10.3233/BEN-2009-0225 |
| spellingShingle | Jason Appel Elizabeth Potter Qian Shen Gustavo Pantol Maria T. Greig David Loewenstein Ranjan Duara A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease Behavioural Neurology |
| title | A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease |
| title_full | A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease |
| title_fullStr | A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease |
| title_full_unstemmed | A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease |
| title_short | A Comparative Analysis of Structural Brain MRI in the Diagnosis of Alzheimer’s Disease |
| title_sort | comparative analysis of structural brain mri in the diagnosis of alzheimer s disease |
| url | http://dx.doi.org/10.3233/BEN-2009-0225 |
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