Sigmoid colon perforation in the patient with granulomatosis with polyangiitis
Abstract Background Granulomatosis with polyangiitis (GPA) induces respiratory tract and kidney granulomatous inflammation due to small-vessel vasculitis. However, gastrointestinal involvement, and especially colon perforation, is rare. Case presentation A 40-year-old man diagnosed with GPA was admi...
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| Format: | Article |
| Language: | English |
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Japan Surgical Society
2019-05-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-019-0646-1 |
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| author | Jun Iwabu Tsutomu Namikawa Hiroyuki Kitagawa Toshichika Kanagawa Junko Nakashima Kazuhiro Hanazaki |
| author_facet | Jun Iwabu Tsutomu Namikawa Hiroyuki Kitagawa Toshichika Kanagawa Junko Nakashima Kazuhiro Hanazaki |
| author_sort | Jun Iwabu |
| collection | DOAJ |
| description | Abstract Background Granulomatosis with polyangiitis (GPA) induces respiratory tract and kidney granulomatous inflammation due to small-vessel vasculitis. However, gastrointestinal involvement, and especially colon perforation, is rare. Case presentation A 40-year-old man diagnosed with GPA was admitted to our hospital for GPA management. He was started on anti-cluster of differentiation 20 antibody (rituximab) therapy after admission and suffered severe abdominal pain 2 weeks later. A clinical diagnosis of sigmoid colon perforation was made, and we performed sigmoid colon resection with colostomy. Histopathological examination revealed loss of vascular wall and neutrophil infiltration. He was discharged from the hospital after intravenous immune globulin therapy. Conclusions Although gastrointestinal involvement is rare in GPA, severe complications require surgical intervention. Bowel perforation should be considered an important complication of GPA. |
| format | Article |
| id | doaj-art-1fc77ae2aa564b379508ccf18159cc88 |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2019-05-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-1fc77ae2aa564b379508ccf18159cc882025-08-20T03:32:49ZengJapan Surgical SocietySurgical Case Reports2198-77932019-05-01511510.1186/s40792-019-0646-1Sigmoid colon perforation in the patient with granulomatosis with polyangiitisJun Iwabu0Tsutomu Namikawa1Hiroyuki Kitagawa2Toshichika Kanagawa3Junko Nakashima4Kazuhiro Hanazaki5Department of Surgery, Kochi Medical SchoolDepartment of Surgery, Kochi Medical SchoolDepartment of Surgery, Kochi Medical SchoolDepartment of Surgery, Kochi Medical SchoolLaboratory of Diagnostic Pathology, Kochi Medical School HospitalDepartment of Surgery, Kochi Medical SchoolAbstract Background Granulomatosis with polyangiitis (GPA) induces respiratory tract and kidney granulomatous inflammation due to small-vessel vasculitis. However, gastrointestinal involvement, and especially colon perforation, is rare. Case presentation A 40-year-old man diagnosed with GPA was admitted to our hospital for GPA management. He was started on anti-cluster of differentiation 20 antibody (rituximab) therapy after admission and suffered severe abdominal pain 2 weeks later. A clinical diagnosis of sigmoid colon perforation was made, and we performed sigmoid colon resection with colostomy. Histopathological examination revealed loss of vascular wall and neutrophil infiltration. He was discharged from the hospital after intravenous immune globulin therapy. Conclusions Although gastrointestinal involvement is rare in GPA, severe complications require surgical intervention. Bowel perforation should be considered an important complication of GPA.http://link.springer.com/article/10.1186/s40792-019-0646-1Granulomatosis with polyangiitisSigmoid colon perforationGastrointestinal involvement |
| spellingShingle | Jun Iwabu Tsutomu Namikawa Hiroyuki Kitagawa Toshichika Kanagawa Junko Nakashima Kazuhiro Hanazaki Sigmoid colon perforation in the patient with granulomatosis with polyangiitis Surgical Case Reports Granulomatosis with polyangiitis Sigmoid colon perforation Gastrointestinal involvement |
| title | Sigmoid colon perforation in the patient with granulomatosis with polyangiitis |
| title_full | Sigmoid colon perforation in the patient with granulomatosis with polyangiitis |
| title_fullStr | Sigmoid colon perforation in the patient with granulomatosis with polyangiitis |
| title_full_unstemmed | Sigmoid colon perforation in the patient with granulomatosis with polyangiitis |
| title_short | Sigmoid colon perforation in the patient with granulomatosis with polyangiitis |
| title_sort | sigmoid colon perforation in the patient with granulomatosis with polyangiitis |
| topic | Granulomatosis with polyangiitis Sigmoid colon perforation Gastrointestinal involvement |
| url | http://link.springer.com/article/10.1186/s40792-019-0646-1 |
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