MiR-138: A promising therapeutic target for cancer
MicroRNAs are small noncoding RNAs which regulate gene expressions at post-transcriptional level by binding to the 3′-untranslated region of target messenger RNAs. Growing evidences highlight their pivotal roles in various biological processes of human cancers. Among them, miR-138, generating from t...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-04-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317697575 |
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| _version_ | 1849709706024583168 |
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| author | Huan-Huan Sha Dan-Dan Wang Dan Chen Si-Wen Liu Zhen Wang Da-Li Yan Shu-Chen Dong Ji-Feng Feng |
| author_facet | Huan-Huan Sha Dan-Dan Wang Dan Chen Si-Wen Liu Zhen Wang Da-Li Yan Shu-Chen Dong Ji-Feng Feng |
| author_sort | Huan-Huan Sha |
| collection | DOAJ |
| description | MicroRNAs are small noncoding RNAs which regulate gene expressions at post-transcriptional level by binding to the 3′-untranslated region of target messenger RNAs. Growing evidences highlight their pivotal roles in various biological processes of human cancers. Among them, miR-138, generating from two primary transcripts, pri-miR-138-1 and pri-miR-138-2, expresses aberrantly in different cancers and is extensively studied in cancer network. Importantly, studies have shown that miR-138 acts as a tumor suppressor by targeting many target genes, which are related to proliferation, apoptosis, invasion, and migration. Additionally, some researches also discover that miR-138 can sensitize tumors to chemotherapies. In this review, we summarize the expression of miR-138 on regulatory mechanisms and tumor biological processes, which will establish molecular basis on the usage of miR-138 in clinical applications in the future. |
| format | Article |
| id | doaj-art-1fc7765e481a4b38a3e904fd2129a75f |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-1fc7765e481a4b38a3e904fd2129a75f2025-08-20T03:15:12ZengSAGE PublishingTumor Biology1423-03802017-04-013910.1177/1010428317697575MiR-138: A promising therapeutic target for cancerHuan-Huan Sha0Dan-Dan Wang1Dan Chen2Si-Wen Liu3Zhen Wang4Da-Li Yan5Shu-Chen Dong6Ji-Feng Feng7Department of Chemotherapy, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaThe First Clinical School of Nanjing Medical University, Nanjing, ChinaResearch Center of Clinical Oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Chemotherapy, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaThe First Clinical School of Nanjing Medical University, Nanjing, ChinaDepartment of Chemotherapy, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Chemotherapy, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Chemotherapy, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaMicroRNAs are small noncoding RNAs which regulate gene expressions at post-transcriptional level by binding to the 3′-untranslated region of target messenger RNAs. Growing evidences highlight their pivotal roles in various biological processes of human cancers. Among them, miR-138, generating from two primary transcripts, pri-miR-138-1 and pri-miR-138-2, expresses aberrantly in different cancers and is extensively studied in cancer network. Importantly, studies have shown that miR-138 acts as a tumor suppressor by targeting many target genes, which are related to proliferation, apoptosis, invasion, and migration. Additionally, some researches also discover that miR-138 can sensitize tumors to chemotherapies. In this review, we summarize the expression of miR-138 on regulatory mechanisms and tumor biological processes, which will establish molecular basis on the usage of miR-138 in clinical applications in the future.https://doi.org/10.1177/1010428317697575 |
| spellingShingle | Huan-Huan Sha Dan-Dan Wang Dan Chen Si-Wen Liu Zhen Wang Da-Li Yan Shu-Chen Dong Ji-Feng Feng MiR-138: A promising therapeutic target for cancer Tumor Biology |
| title | MiR-138: A promising therapeutic target for cancer |
| title_full | MiR-138: A promising therapeutic target for cancer |
| title_fullStr | MiR-138: A promising therapeutic target for cancer |
| title_full_unstemmed | MiR-138: A promising therapeutic target for cancer |
| title_short | MiR-138: A promising therapeutic target for cancer |
| title_sort | mir 138 a promising therapeutic target for cancer |
| url | https://doi.org/10.1177/1010428317697575 |
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