Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model
Backgrounds. Limited effective palliative treatments exist for pancreatic cancer which includes surgery or chemotherapy. Radiofrequency ablation (RFA) uses high frequency alternating current to ablate diseased tissue and has been used to treat various tumors. In this study, we evaluated a prototype...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/431451 |
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| author | Monica Gaidhane Ioana Smith Kristi Ellen Jeremy Gatesman Nagy Habib Patricia Foley Christopher Moskaluk Michel Kahaleh |
| author_facet | Monica Gaidhane Ioana Smith Kristi Ellen Jeremy Gatesman Nagy Habib Patricia Foley Christopher Moskaluk Michel Kahaleh |
| author_sort | Monica Gaidhane |
| collection | DOAJ |
| description | Backgrounds. Limited effective palliative treatments exist for pancreatic cancer which includes surgery or chemotherapy. Radiofrequency ablation (RFA) uses high frequency alternating current to ablate diseased tissue and has been used to treat various tumors. In this study, we evaluated a prototype probe adjusted to the EUS-needle to perform EUS-RFA to permit coagulative necrosis in the pancreas. Methods. Five Yucatan pigs underwent EUS-guided radiofrequency ablation of the head of their pancreas. Using an EUS-needle, RFA was applied with 6 mm and then 10 mm of the probe exposed at specific wattage for preset durations. Results. Only one pig showed moderate levels of pancreatitis (20% proximal pancreatitis). The other animals showed much lower areas of tissue damage. In 3 of the 5 pigs, the proximal pancreas showed greater levels of tissue injury than the distal pancreas, consistent with the proximity of the tissue to the procedure site. In 1 pig, both proximal and distal pancreas showed minimal pancreatitis (1%). There was minimal evidence of fat necrosis in intra-pancreatic and/or extra-pancreatic adipose tissue. Conclusion. EUS-guided RFA of the pancreatic head with the monopolar probe through a 19-gauge needle was well tolerated in 5 Yucatan pigs and with minimal amount of pancreatitis. |
| format | Article |
| id | doaj-art-1fc6b9ddd6574f02bfcd3b1fa1017b22 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-1fc6b9ddd6574f02bfcd3b1fa1017b222025-08-20T02:03:47ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/431451431451Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine ModelMonica Gaidhane0Ioana Smith1Kristi Ellen2Jeremy Gatesman3Nagy Habib4Patricia Foley5Christopher Moskaluk6Michel Kahaleh7Division of Gastroenterology & Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USASchool of Medicine, University of Virginia, Charlottesville, VA 22903, USASchool of Medicine, University of Virginia, Charlottesville, VA 22903, USASchool of Medicine, University of Virginia, Charlottesville, VA 22903, USADepartment of Surgery and Cancer, Imperial College, London SW7 2AZ, UKSchool of Medicine, University of Virginia, Charlottesville, VA 22903, USASchool of Medicine, University of Virginia, Charlottesville, VA 22903, USADivision of Gastroenterology & Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USABackgrounds. Limited effective palliative treatments exist for pancreatic cancer which includes surgery or chemotherapy. Radiofrequency ablation (RFA) uses high frequency alternating current to ablate diseased tissue and has been used to treat various tumors. In this study, we evaluated a prototype probe adjusted to the EUS-needle to perform EUS-RFA to permit coagulative necrosis in the pancreas. Methods. Five Yucatan pigs underwent EUS-guided radiofrequency ablation of the head of their pancreas. Using an EUS-needle, RFA was applied with 6 mm and then 10 mm of the probe exposed at specific wattage for preset durations. Results. Only one pig showed moderate levels of pancreatitis (20% proximal pancreatitis). The other animals showed much lower areas of tissue damage. In 3 of the 5 pigs, the proximal pancreas showed greater levels of tissue injury than the distal pancreas, consistent with the proximity of the tissue to the procedure site. In 1 pig, both proximal and distal pancreas showed minimal pancreatitis (1%). There was minimal evidence of fat necrosis in intra-pancreatic and/or extra-pancreatic adipose tissue. Conclusion. EUS-guided RFA of the pancreatic head with the monopolar probe through a 19-gauge needle was well tolerated in 5 Yucatan pigs and with minimal amount of pancreatitis.http://dx.doi.org/10.1155/2012/431451 |
| spellingShingle | Monica Gaidhane Ioana Smith Kristi Ellen Jeremy Gatesman Nagy Habib Patricia Foley Christopher Moskaluk Michel Kahaleh Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model Gastroenterology Research and Practice |
| title | Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model |
| title_full | Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model |
| title_fullStr | Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model |
| title_full_unstemmed | Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model |
| title_short | Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model |
| title_sort | endoscopic ultrasound guided radiofrequency ablation eus rfa of the pancreas in a porcine model |
| url | http://dx.doi.org/10.1155/2012/431451 |
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