Antidiabetic agents as potential cytotoxic candidates for cancer therapy
Hyperglycemia is an overlooked triggering factor for cancer, despite being critical to the survival and growth of cancer cells through a unique process known as the “Warburg effect.” Therefore, blocking glycolysis by using antidiabetic agents is an attractive approach for impeding cancer growth and...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2025-06-01
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| Series: | Forum of Clinical Oncology |
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| Online Access: | https://doi.org/10.2478/fco-2023-0041 |
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| _version_ | 1849225006671724544 |
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| author | Alnaser Raniah I. Alassaf Fawaz A. Abed Mohammed N. |
| author_facet | Alnaser Raniah I. Alassaf Fawaz A. Abed Mohammed N. |
| author_sort | Alnaser Raniah I. |
| collection | DOAJ |
| description | Hyperglycemia is an overlooked triggering factor for cancer, despite being critical to the survival and growth of cancer cells through a unique process known as the “Warburg effect.” Therefore, blocking glycolysis by using antidiabetic agents is an attractive approach for impeding cancer growth and enhancing their responsiveness to cancer treatments, while leaving healthy cells unaffected. This review aims to explore the potential of antidiabetics as cytotoxic agents for cancer treatment through their role as glucose deprivation candidates and the clinical considerations of using antidiabetics with their risk as carcinogenic in cancer therapy. |
| format | Article |
| id | doaj-art-1fc67161d23745d6929b6d24b65b9d33 |
| institution | Kabale University |
| issn | 1792-362X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Forum of Clinical Oncology |
| spelling | doaj-art-1fc67161d23745d6929b6d24b65b9d332025-08-25T06:11:53ZengSciendoForum of Clinical Oncology1792-362X2025-06-01151688910.2478/fco-2023-0041Antidiabetic agents as potential cytotoxic candidates for cancer therapyAlnaser Raniah I.0Alassaf Fawaz A.1Abed Mohammed N.2Nineveh Health Directorate, Mosul, Nineveh province, IraqUniversity of Mosul, College of Pharmacy, Department of Pharmacology and Toxicology, Mosul, Nineveh province, 41002, IraqUniversity of Mosul, College of Pharmacy, Department of Clinical Laboratory Sciences, Mosul, Nineveh province, 41002, IraqHyperglycemia is an overlooked triggering factor for cancer, despite being critical to the survival and growth of cancer cells through a unique process known as the “Warburg effect.” Therefore, blocking glycolysis by using antidiabetic agents is an attractive approach for impeding cancer growth and enhancing their responsiveness to cancer treatments, while leaving healthy cells unaffected. This review aims to explore the potential of antidiabetics as cytotoxic agents for cancer treatment through their role as glucose deprivation candidates and the clinical considerations of using antidiabetics with their risk as carcinogenic in cancer therapy.https://doi.org/10.2478/fco-2023-0041cancerdiabetes mellitusglucose deprivationantidiabeticscytotoxicity |
| spellingShingle | Alnaser Raniah I. Alassaf Fawaz A. Abed Mohammed N. Antidiabetic agents as potential cytotoxic candidates for cancer therapy Forum of Clinical Oncology cancer diabetes mellitus glucose deprivation antidiabetics cytotoxicity |
| title | Antidiabetic agents as potential cytotoxic candidates for cancer therapy |
| title_full | Antidiabetic agents as potential cytotoxic candidates for cancer therapy |
| title_fullStr | Antidiabetic agents as potential cytotoxic candidates for cancer therapy |
| title_full_unstemmed | Antidiabetic agents as potential cytotoxic candidates for cancer therapy |
| title_short | Antidiabetic agents as potential cytotoxic candidates for cancer therapy |
| title_sort | antidiabetic agents as potential cytotoxic candidates for cancer therapy |
| topic | cancer diabetes mellitus glucose deprivation antidiabetics cytotoxicity |
| url | https://doi.org/10.2478/fco-2023-0041 |
| work_keys_str_mv | AT alnaserraniahi antidiabeticagentsaspotentialcytotoxiccandidatesforcancertherapy AT alassaffawaza antidiabeticagentsaspotentialcytotoxiccandidatesforcancertherapy AT abedmohammedn antidiabeticagentsaspotentialcytotoxiccandidatesforcancertherapy |