Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg2+ for Delayed Drug Release in the Digestive System
Curcumin-loaded chitosan-pectin microparticles based on polymeric microencapsulation were prepared by two methods to delay the release of curcumin in the digestive system, employing Mg2+ as a pectin-crosslinking agent for the first time. Pectin-coated curcumin-chitosan microparticles (C-g-PMg) and c...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2018/2071071 |
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| _version_ | 1832560300144984064 |
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| author | Seung Won Hwang Jae Sup Shin |
| author_facet | Seung Won Hwang Jae Sup Shin |
| author_sort | Seung Won Hwang |
| collection | DOAJ |
| description | Curcumin-loaded chitosan-pectin microparticles based on polymeric microencapsulation were prepared by two methods to delay the release of curcumin in the digestive system, employing Mg2+ as a pectin-crosslinking agent for the first time. Pectin-coated curcumin-chitosan microparticles (C-g-PMg) and curcumin-loaded chitosan-pectin composite microparticles (C-PMg-g) were formulated, and their release profiles at pH 1.2 and at pH 6.8 were tested. The former (C-g-PMg) showed slower curcumin release profiles than the latter (C-PMg-g) because the C-g-PMg are composed of two layers, a chitosan-glutaraldehyde layer and a pectin-Mg2+ layer, which together hold the curcumin for a longer duration. Of the pectin-coated microparticles, those crosslinked with Mg2+ showed a slower release rate than those crosslinked with Ca2+, but the former showed a faster release rate at pH 6.8 in the presence of pectinase, acting as a promising drug delivery carrier for treating a colonic disease. The pectin layer and a pectin-crosslinking agent plays a vital role in prolonging the release of curcumin until pectin is degraded by pectinase. |
| format | Article |
| id | doaj-art-1fc54e133c194673b469428946df6d56 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-1fc54e133c194673b469428946df6d562025-02-03T01:27:54ZengWileyInternational Journal of Polymer Science1687-94221687-94302018-01-01201810.1155/2018/20710712071071Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg2+ for Delayed Drug Release in the Digestive SystemSeung Won Hwang0Jae Sup Shin1Department of Chemistry, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of KoreaDepartment of Chemistry, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of KoreaCurcumin-loaded chitosan-pectin microparticles based on polymeric microencapsulation were prepared by two methods to delay the release of curcumin in the digestive system, employing Mg2+ as a pectin-crosslinking agent for the first time. Pectin-coated curcumin-chitosan microparticles (C-g-PMg) and curcumin-loaded chitosan-pectin composite microparticles (C-PMg-g) were formulated, and their release profiles at pH 1.2 and at pH 6.8 were tested. The former (C-g-PMg) showed slower curcumin release profiles than the latter (C-PMg-g) because the C-g-PMg are composed of two layers, a chitosan-glutaraldehyde layer and a pectin-Mg2+ layer, which together hold the curcumin for a longer duration. Of the pectin-coated microparticles, those crosslinked with Mg2+ showed a slower release rate than those crosslinked with Ca2+, but the former showed a faster release rate at pH 6.8 in the presence of pectinase, acting as a promising drug delivery carrier for treating a colonic disease. The pectin layer and a pectin-crosslinking agent plays a vital role in prolonging the release of curcumin until pectin is degraded by pectinase.http://dx.doi.org/10.1155/2018/2071071 |
| spellingShingle | Seung Won Hwang Jae Sup Shin Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg2+ for Delayed Drug Release in the Digestive System International Journal of Polymer Science |
| title | Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg2+ for Delayed Drug Release in the Digestive System |
| title_full | Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg2+ for Delayed Drug Release in the Digestive System |
| title_fullStr | Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg2+ for Delayed Drug Release in the Digestive System |
| title_full_unstemmed | Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg2+ for Delayed Drug Release in the Digestive System |
| title_short | Pectin-Coated Curcumin-Chitosan Microparticles Crosslinked with Mg2+ for Delayed Drug Release in the Digestive System |
| title_sort | pectin coated curcumin chitosan microparticles crosslinked with mg2 for delayed drug release in the digestive system |
| url | http://dx.doi.org/10.1155/2018/2071071 |
| work_keys_str_mv | AT seungwonhwang pectincoatedcurcuminchitosanmicroparticlescrosslinkedwithmg2fordelayeddrugreleaseinthedigestivesystem AT jaesupshin pectincoatedcurcuminchitosanmicroparticlescrosslinkedwithmg2fordelayeddrugreleaseinthedigestivesystem |