Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-γ and Plasminogen Activator Inhibitor-1
Breast cancer is the most prominent cancer among females in the United States. There are a number of risk factors associated with development of breast cancer, including consumption of a high-fat diet and obesity. Plasminogen activator inhibitor-1 (PAI-1) is a cytokine upregulated in obesity whose e...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2009/345320 |
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| _version_ | 1849307997527867392 |
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| author | Jennifer C. Carter Frank C. Church |
| author_facet | Jennifer C. Carter Frank C. Church |
| author_sort | Jennifer C. Carter |
| collection | DOAJ |
| description | Breast cancer is the most prominent cancer among females in the United States. There are a number of risk factors associated with development of breast cancer, including consumption of a high-fat diet and obesity. Plasminogen activator inhibitor-1 (PAI-1) is a cytokine upregulated in obesity whose expression is correlated with a poor prognosis in breast cancer. As a key mediator of adipogenesis and regulator of adipokine production, peroxisome proliferator-activated receptor-γ (PPAR-γ) is involved in PAI-1 expression from adipose tissue. We summarize the current knowledge linking PPAR-γ and PAI-1 expression to high-fat diet and obesity in the risk of breast cancer. |
| format | Article |
| id | doaj-art-1fc1cbf7962c45fa839413c3c2eba2b3 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-1fc1cbf7962c45fa839413c3c2eba2b32025-08-20T03:54:36ZengWileyPPAR Research1687-47571687-47652009-01-01200910.1155/2009/345320345320Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-γ and Plasminogen Activator Inhibitor-1Jennifer C. Carter0Frank C. Church1Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7035, USADepartment of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599-7035, USABreast cancer is the most prominent cancer among females in the United States. There are a number of risk factors associated with development of breast cancer, including consumption of a high-fat diet and obesity. Plasminogen activator inhibitor-1 (PAI-1) is a cytokine upregulated in obesity whose expression is correlated with a poor prognosis in breast cancer. As a key mediator of adipogenesis and regulator of adipokine production, peroxisome proliferator-activated receptor-γ (PPAR-γ) is involved in PAI-1 expression from adipose tissue. We summarize the current knowledge linking PPAR-γ and PAI-1 expression to high-fat diet and obesity in the risk of breast cancer.http://dx.doi.org/10.1155/2009/345320 |
| spellingShingle | Jennifer C. Carter Frank C. Church Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-γ and Plasminogen Activator Inhibitor-1 PPAR Research |
| title | Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-γ and Plasminogen Activator Inhibitor-1 |
| title_full | Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-γ and Plasminogen Activator Inhibitor-1 |
| title_fullStr | Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-γ and Plasminogen Activator Inhibitor-1 |
| title_full_unstemmed | Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-γ and Plasminogen Activator Inhibitor-1 |
| title_short | Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-γ and Plasminogen Activator Inhibitor-1 |
| title_sort | obesity and breast cancer the roles of peroxisome proliferator activated receptor γ and plasminogen activator inhibitor 1 |
| url | http://dx.doi.org/10.1155/2009/345320 |
| work_keys_str_mv | AT jenniferccarter obesityandbreastcancertherolesofperoxisomeproliferatoractivatedreceptorgandplasminogenactivatorinhibitor1 AT frankcchurch obesityandbreastcancertherolesofperoxisomeproliferatoractivatedreceptorgandplasminogenactivatorinhibitor1 |