Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain

Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain

Monoclonal neutralizing antibodies (mAbs) are considered an important prophylactic against SARS-CoV-2 infection in at-risk populations and a strategy to counteract future sarbecovirus-induced disease. However, most mAbs isolated so far neutralize only a few sarbecovirus strains. Therefore, there is...

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Bibliographic Details
Main Authors: Denise Guerra, Laura Radić, Mitch Brinkkemper, Meliawati Poniman, Lara van der Maas, Jonathan L. Torres, Andrew B. Ward, Kwinten Sliepen, Janke Schinkel, Rogier W. Sanders, Marit J. van Gils, Tim Beaumont
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
SARS-CoV-2
variants
sarbecoviruses
bispecific antibodies
cross-reactivity
breadth
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2024.2388344
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