Navigating the intersection of mental health and kidney health: a systematic review of antidepressant safety in renal impairment
Abstract Depression is a prevalent mental health condition that significantly impacts adults with impaired renal function, yet the safety and efficacy of antidepressants in this population remain inadequately explored. Understanding how renal impairment affects antidepressant pharmacokinetics and cl...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-03-01
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| Series: | Discover Mental Health |
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| Online Access: | https://doi.org/10.1007/s44192-025-00163-z |
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| _version_ | 1849390148757749760 |
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| author | Hooria Sarwar Muhammad Zeshan Najeeb Hussain Esha Mogali Rehan Durrani Iana Malasevskaia |
| author_facet | Hooria Sarwar Muhammad Zeshan Najeeb Hussain Esha Mogali Rehan Durrani Iana Malasevskaia |
| author_sort | Hooria Sarwar |
| collection | DOAJ |
| description | Abstract Depression is a prevalent mental health condition that significantly impacts adults with impaired renal function, yet the safety and efficacy of antidepressants in this population remain inadequately explored. Understanding how renal impairment affects antidepressant pharmacokinetics and clinical outcomes is essential for optimizing treatment strategies. This systematic review adhered to PRISMA 2020 guidelines, conducting a comprehensive literature search across multiple databases, including PubMed, ScienceDirect, ClinicalTrial.gov, and Medline. Studies were included if they evaluated the use of antidepressants in adults with renal impairment, assessing both safety and efficacy outcomes. The review identified 11 studies that met the inclusion criteria, with sample sizes ranging from 30 to 101,409 participants, yielding a total sample size of 192,684. The quality assessment of the included studies was conducted based on the type of study design, focusing on methodological rigor and relevance to the research question. While certain antidepressants demonstrate efficacy, their pharmacokinetic profiles necessitate careful monitoring and dose adjustments in patients with different levels of renal impairment. These insights underscore the need for individualized treatment approaches and highlight areas for future research to enhance care for this vulnerable population. |
| format | Article |
| id | doaj-art-1fb32f190fc84c2d8a66105ec35e636c |
| institution | Kabale University |
| issn | 2731-4383 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Mental Health |
| spelling | doaj-art-1fb32f190fc84c2d8a66105ec35e636c2025-08-20T03:41:46ZengSpringerDiscover Mental Health2731-43832025-03-015111810.1007/s44192-025-00163-zNavigating the intersection of mental health and kidney health: a systematic review of antidepressant safety in renal impairmentHooria Sarwar0Muhammad Zeshan1Najeeb Hussain2Esha Mogali3Rehan Durrani4Iana Malasevskaia5Fatima Jinnah Medical UniversityRutgers Robert Wood Johnson Medical SchoolRutgers Robert Wood Johnson Medical SchoolInside Out CURE PsychiatryInside Out CURE PsychiatryPrivate Clinic of Obstetrics and GynaecologyAbstract Depression is a prevalent mental health condition that significantly impacts adults with impaired renal function, yet the safety and efficacy of antidepressants in this population remain inadequately explored. Understanding how renal impairment affects antidepressant pharmacokinetics and clinical outcomes is essential for optimizing treatment strategies. This systematic review adhered to PRISMA 2020 guidelines, conducting a comprehensive literature search across multiple databases, including PubMed, ScienceDirect, ClinicalTrial.gov, and Medline. Studies were included if they evaluated the use of antidepressants in adults with renal impairment, assessing both safety and efficacy outcomes. The review identified 11 studies that met the inclusion criteria, with sample sizes ranging from 30 to 101,409 participants, yielding a total sample size of 192,684. The quality assessment of the included studies was conducted based on the type of study design, focusing on methodological rigor and relevance to the research question. While certain antidepressants demonstrate efficacy, their pharmacokinetic profiles necessitate careful monitoring and dose adjustments in patients with different levels of renal impairment. These insights underscore the need for individualized treatment approaches and highlight areas for future research to enhance care for this vulnerable population.https://doi.org/10.1007/s44192-025-00163-zChronic kidney diseaseHemodialysisAntidepressantsESRDSafety profileSide effects |
| spellingShingle | Hooria Sarwar Muhammad Zeshan Najeeb Hussain Esha Mogali Rehan Durrani Iana Malasevskaia Navigating the intersection of mental health and kidney health: a systematic review of antidepressant safety in renal impairment Discover Mental Health Chronic kidney disease Hemodialysis Antidepressants ESRD Safety profile Side effects |
| title | Navigating the intersection of mental health and kidney health: a systematic review of antidepressant safety in renal impairment |
| title_full | Navigating the intersection of mental health and kidney health: a systematic review of antidepressant safety in renal impairment |
| title_fullStr | Navigating the intersection of mental health and kidney health: a systematic review of antidepressant safety in renal impairment |
| title_full_unstemmed | Navigating the intersection of mental health and kidney health: a systematic review of antidepressant safety in renal impairment |
| title_short | Navigating the intersection of mental health and kidney health: a systematic review of antidepressant safety in renal impairment |
| title_sort | navigating the intersection of mental health and kidney health a systematic review of antidepressant safety in renal impairment |
| topic | Chronic kidney disease Hemodialysis Antidepressants ESRD Safety profile Side effects |
| url | https://doi.org/10.1007/s44192-025-00163-z |
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