The role of pathogenic germline mutations of BRCA1/2, NBS1, and CHEK2 genes in gastric cancer development within the Volga-Ural region of Russia

The role of pathogenic germline mutations of BRCA1/2, NBS1, and CHEK2 genes in gastric cancer development within the Volga-Ural region of Russia

Background and objective — Gastric cancer (GC) is one of the most common cancers worldwide with a high mortality rate. Hereditary predisposition to GC is still not fully understood. The objective of this study was to compare the prevalence of mutations in the BRCA1 (c.68_69delAG, c.4035delA, c.5266d...

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Bibliographic Details
Main Authors: Alfiia Kh. Nurgalieva, Sabina G. Petrova, Lilia F. Gallyamova, Natalia V. Ekomasova, Dina D. Sakaeva, Yulia Yu. Fedorova, Murat A. Dzhaubermezov, Rustem R. Abdeev, Radmir R. Rakhimov, Elza K. Khusnutdinova, Darya S. Prokofyeva
Format: Article
Language:English
Published: Limited liability company «Science and Innovations» (Saratov) 2025-03-01
Series:Russian Open Medical Journal
Subjects:
gastric cancer
mutation
germline mutation
pathogenic variant
Online Access:https://romj.org/node/596
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