Sialylation as a checkpoint for inflammatory and complement-related retinal diseases

Sialylation as a checkpoint for inflammatory and complement-related retinal diseases

Sialylation is a modification process involving the addition of sialic acid residues to the termini of glycoproteins and glycolipids in mammalian cells. Sialylation serves as a crucial checkpoint inhibitor of the complement and immune systems, particularly within the central nervous system (CNS), in...

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Bibliographic Details
Main Authors: Yiduo Min, German Cuevas-Rios, Thomas Langmann, Harald Neumann
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
retina
sialylation
sialic acid
polysialic acid
complement
microglia
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1623755/full
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