METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD
A procedure for the simantenous determination of aminotriazole, triazolopyrimidinone and nirotriazolopyrimidinone was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted aminophase Zorbax NH2 (Agilent T...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/503 |
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| author | A. V. Baklykov A. A. Tumashov S. K. Kotovskaya E. N. Ulomskiy G. L. Rusinov V. L. Rusinov D. S. Kopchuk O. N. Chupakhin V. N. Charushin |
| author_facet | A. V. Baklykov A. A. Tumashov S. K. Kotovskaya E. N. Ulomskiy G. L. Rusinov V. L. Rusinov D. S. Kopchuk O. N. Chupakhin V. N. Charushin |
| author_sort | A. V. Baklykov |
| collection | DOAJ |
| description | A procedure for the simantenous determination of aminotriazole, triazolopyrimidinone and nirotriazolopyrimidinone was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted aminophase Zorbax NH2 (Agilent Technologies, USA). The possibility of applying the developed methodology for the technological control of the second stage of the drug «Triazid» preparation is established following the results of the validation. |
| format | Article |
| id | doaj-art-1fa4287d9c6241f3b8f27892ed268400 |
| institution | DOAJ |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-1fa4287d9c6241f3b8f27892ed2684002025-08-20T03:19:32ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-010498102503METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHODA. V. Baklykov0A. A. Tumashov1S. K. Kotovskaya2E. N. Ulomskiy3G. L. Rusinov4V. L. Rusinov5D. S. Kopchuk6O. N. Chupakhin7V. N. Charushin8I.Ya. Postovsky Institute of Organic Synthesis UB of RASI.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinI.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS; Ural Federal University named after the first president of Russia B.N. YeltsinA procedure for the simantenous determination of aminotriazole, triazolopyrimidinone and nirotriazolopyrimidinone was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted aminophase Zorbax NH2 (Agilent Technologies, USA). The possibility of applying the developed methodology for the technological control of the second stage of the drug «Triazid» preparation is established following the results of the validation.https://www.pharmjournal.ru/jour/article/view/503aminotriazoletriazolopyrimidinonenirotriazolopyrimidinonetriazidehplcvalidation |
| spellingShingle | A. V. Baklykov A. A. Tumashov S. K. Kotovskaya E. N. Ulomskiy G. L. Rusinov V. L. Rusinov D. S. Kopchuk O. N. Chupakhin V. N. Charushin METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD Разработка и регистрация лекарственных средств aminotriazole triazolopyrimidinone nirotriazolopyrimidinone triazide hplc validation |
| title | METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD |
| title_full | METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD |
| title_fullStr | METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD |
| title_full_unstemmed | METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD |
| title_short | METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD |
| title_sort | method of simantenous determination of aminotriazole triazolopyrimidinone and nitrotriazolopirimidinone substrate and semi products of synthesis of drug triazid by hplc method |
| topic | aminotriazole triazolopyrimidinone nirotriazolopyrimidinone triazide hplc validation |
| url | https://www.pharmjournal.ru/jour/article/view/503 |
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