Seeding activity of skin misfolded tau as a biomarker for tauopathies

Seeding activity of skin misfolded tau as a biomarker for tauopathies

Abstract Background Tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically hyperphosphorylated tau protein in the brain, leading to prion-like aggregation and propagation. They include Alzheimer’s disease (AD), progressive supranuclear p...

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Main Authors: Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Zahid Syed Ali Shah, Evalynn Lomax, Yirong Yang, Steven A. Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zou
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Neurodegeneration
Subjects:
Tauopathies
Alzheimer’s disease
Seeding activity
Tau
Real-time quaking-induced conversion (RT-QuIC)
Skin
Online Access:https://doi.org/10.1186/s13024-024-00781-1
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