Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19
Introduction. The true impact of prediabetes and type-2 diabetes in patients with COVID-19 remains unknown, with studies thus far providing conflicting evidence. Methods. This is a single-center retrospective observational study involving 843 hospitalized patients with SARS-CoV-2 infection. Primary...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/5516192 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850229409555939328 |
|---|---|
| author | Jasbir Makker Haozhe Sun Harish Patel Nikhitha Mantri Maleeha Zahid Sudharsan Gongati Sneha Galiveeti Sharon W. Renner Sridhar Chilimuri |
| author_facet | Jasbir Makker Haozhe Sun Harish Patel Nikhitha Mantri Maleeha Zahid Sudharsan Gongati Sneha Galiveeti Sharon W. Renner Sridhar Chilimuri |
| author_sort | Jasbir Makker |
| collection | DOAJ |
| description | Introduction. The true impact of prediabetes and type-2 diabetes in patients with COVID-19 remains unknown, with studies thus far providing conflicting evidence. Methods. This is a single-center retrospective observational study involving 843 hospitalized patients with SARS-CoV-2 infection. Primary outcomes, mortality, and mechanical ventilation use were compared among the three groups: control, prediabetes, and type-2 diabetes. Binomial regression analysis was used to determine predictors of mortality and mechanical ventilation requirement. Results. Age was a significant predictor of mortality. On stratifying our patients based on their age, older patients aged 55 years and above had no difference in mortality or mechanical ventilation requirement among the three groups of control, prediabetes, and type-2 diabetes. However, among the younger population aged less than 55 years, patients with type-2 diabetes had significantly higher mortality as compared with patients in control and prediabetes groups (27% vs 12.5% vs 9%, p 0.025). Additionally, newly diagnosed type-2 diabetes patients demonstrated lower mortality rate in comparison to previously known type-2 diabetes patients (18% vs 40%, p 0.005). Outcomes in the prediabetes group were similar to that in the control group. Admission hyperglycemia was associated with higher mortality regardless of diabetes status. Conclusion. In older patients aged 55 years and above, status of type-2 diabetes does not influence their mortality. However, in younger patients aged less than 55 years, the presence of type-2 diabetes is an important driver of mortality. Newly diagnosed type-2 diabetes, in comparison with previously diagnosed type-2 diabetes, may have better survival. Presence of prediabetes did not affect outcomes in patients with COVID-19 infection. |
| format | Article |
| id | doaj-art-1f904e5b4e6743a99f06210bb298dad1 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1f904e5b4e6743a99f06210bb298dad12025-08-20T02:04:14ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/55161925516192Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19Jasbir Makker0Haozhe Sun1Harish Patel2Nikhitha Mantri3Maleeha Zahid4Sudharsan Gongati5Sneha Galiveeti6Sharon W. Renner7Sridhar Chilimuri8Department of Medicine, Bronxcare Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, NY, USADepartment of Medicine, Bronxcare Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, NY, USADepartment of Medicine, Bronxcare Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, NY, USADepartment of Medicine, Bronxcare Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, NY, USADepartment of Medicine, Bronxcare Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, NY, USADepartment of Medicine, Bronxcare Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, NY, USADepartment of Medicine, Bronxcare Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, NY, USADepartment of Kinesiology and Health Sciences, Columbus State University, Columbus, GeorgiaDepartment of Medicine, Bronxcare Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, New York, NY, USAIntroduction. The true impact of prediabetes and type-2 diabetes in patients with COVID-19 remains unknown, with studies thus far providing conflicting evidence. Methods. This is a single-center retrospective observational study involving 843 hospitalized patients with SARS-CoV-2 infection. Primary outcomes, mortality, and mechanical ventilation use were compared among the three groups: control, prediabetes, and type-2 diabetes. Binomial regression analysis was used to determine predictors of mortality and mechanical ventilation requirement. Results. Age was a significant predictor of mortality. On stratifying our patients based on their age, older patients aged 55 years and above had no difference in mortality or mechanical ventilation requirement among the three groups of control, prediabetes, and type-2 diabetes. However, among the younger population aged less than 55 years, patients with type-2 diabetes had significantly higher mortality as compared with patients in control and prediabetes groups (27% vs 12.5% vs 9%, p 0.025). Additionally, newly diagnosed type-2 diabetes patients demonstrated lower mortality rate in comparison to previously known type-2 diabetes patients (18% vs 40%, p 0.005). Outcomes in the prediabetes group were similar to that in the control group. Admission hyperglycemia was associated with higher mortality regardless of diabetes status. Conclusion. In older patients aged 55 years and above, status of type-2 diabetes does not influence their mortality. However, in younger patients aged less than 55 years, the presence of type-2 diabetes is an important driver of mortality. Newly diagnosed type-2 diabetes, in comparison with previously diagnosed type-2 diabetes, may have better survival. Presence of prediabetes did not affect outcomes in patients with COVID-19 infection.http://dx.doi.org/10.1155/2021/5516192 |
| spellingShingle | Jasbir Makker Haozhe Sun Harish Patel Nikhitha Mantri Maleeha Zahid Sudharsan Gongati Sneha Galiveeti Sharon W. Renner Sridhar Chilimuri Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19 International Journal of Endocrinology |
| title | Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19 |
| title_full | Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19 |
| title_fullStr | Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19 |
| title_full_unstemmed | Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19 |
| title_short | Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19 |
| title_sort | impact of prediabetes and type 2 diabetes on outcomes in patients with covid 19 |
| url | http://dx.doi.org/10.1155/2021/5516192 |
| work_keys_str_mv | AT jasbirmakker impactofprediabetesandtype2diabetesonoutcomesinpatientswithcovid19 AT haozhesun impactofprediabetesandtype2diabetesonoutcomesinpatientswithcovid19 AT harishpatel impactofprediabetesandtype2diabetesonoutcomesinpatientswithcovid19 AT nikhithamantri impactofprediabetesandtype2diabetesonoutcomesinpatientswithcovid19 AT maleehazahid impactofprediabetesandtype2diabetesonoutcomesinpatientswithcovid19 AT sudharsangongati impactofprediabetesandtype2diabetesonoutcomesinpatientswithcovid19 AT snehagaliveeti impactofprediabetesandtype2diabetesonoutcomesinpatientswithcovid19 AT sharonwrenner impactofprediabetesandtype2diabetesonoutcomesinpatientswithcovid19 AT sridharchilimuri impactofprediabetesandtype2diabetesonoutcomesinpatientswithcovid19 |