Treatment results of chronic hepatitis B in children: a retrospective study
In this retrospective study, we aimed to share our experience with different treatment modalities for chronic hepatitis B in a series of children. The study included 126 children (mean: 9.5 +/- 3.8 years). Normalization of alanine aminotransferase (ALT), loss of hepatitis B virus (HBV)-DNA an...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2010-08-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/5019 |
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| author | Mukadder Ayşe Selimoğlu Vildan Ertekin Hamza Karabiber Ahmet Turgut Nesrin Gürsan |
| author_facet | Mukadder Ayşe Selimoğlu Vildan Ertekin Hamza Karabiber Ahmet Turgut Nesrin Gürsan |
| author_sort | Mukadder Ayşe Selimoğlu |
| collection | DOAJ |
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In this retrospective study, we aimed to share our experience with different treatment modalities for chronic hepatitis B in a series of children. The study included 126 children (mean: 9.5 +/- 3.8 years). Normalization of alanine aminotransferase (ALT), loss of hepatitis B virus (HBV)-DNA and hepatitis B e antigen (HBeAg), and development of antibody to HBeAg (anti-HBe) altogether at the end of the treatment was considered as end of therapy response (ETR). Seroconversion ongoing one year after the cessation of therapy was considered as sustained response. Of the total children, 90 (71.4%) were treated, whereas the remaining were just followed-up. High-dose interferon (IFN)-alpha (10 MU/m2) alone, standard-dose IFN-alpha (6 MU/m2) plus lamivudine (4 mg/kg/d), high-dose IFN-alpha plus lamivudine, or lamivudine alone was used, IFN-alpha thrice weekly for six months, and lamivudine daily for one year. Of children who had completed their treatment, 34 (37.8%) achieved ETR. Sustained response rate was 36.7%. Response rates were different in the different treatment groups (p: 0.01). The highest response rate was observed in those who received standard-dose IFN-alpha plus lamivudine treatment (61.5%). Of children without treatment, one (2.8%) had anti-HBe seroconversion. Standard-dose IFN-alpha plus lamivudine treatment was found superior to the other treatment modalities. Predictors of ETR were similar to those found in previous studies.
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| format | Article |
| id | doaj-art-1f8c42b9a9be4c2c8d1a39e978cbabe8 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2010-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-1f8c42b9a9be4c2c8d1a39e978cbabe82025-08-20T03:16:22ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212010-08-01524Treatment results of chronic hepatitis B in children: a retrospective studyMukadder Ayşe Selimoğlu0Vildan ErtekinHamza KarabiberAhmet TurgutNesrin GürsanDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Inönü University Faculty of Medicine, Malatya, Turkey. In this retrospective study, we aimed to share our experience with different treatment modalities for chronic hepatitis B in a series of children. The study included 126 children (mean: 9.5 +/- 3.8 years). Normalization of alanine aminotransferase (ALT), loss of hepatitis B virus (HBV)-DNA and hepatitis B e antigen (HBeAg), and development of antibody to HBeAg (anti-HBe) altogether at the end of the treatment was considered as end of therapy response (ETR). Seroconversion ongoing one year after the cessation of therapy was considered as sustained response. Of the total children, 90 (71.4%) were treated, whereas the remaining were just followed-up. High-dose interferon (IFN)-alpha (10 MU/m2) alone, standard-dose IFN-alpha (6 MU/m2) plus lamivudine (4 mg/kg/d), high-dose IFN-alpha plus lamivudine, or lamivudine alone was used, IFN-alpha thrice weekly for six months, and lamivudine daily for one year. Of children who had completed their treatment, 34 (37.8%) achieved ETR. Sustained response rate was 36.7%. Response rates were different in the different treatment groups (p: 0.01). The highest response rate was observed in those who received standard-dose IFN-alpha plus lamivudine treatment (61.5%). Of children without treatment, one (2.8%) had anti-HBe seroconversion. Standard-dose IFN-alpha plus lamivudine treatment was found superior to the other treatment modalities. Predictors of ETR were similar to those found in previous studies. https://turkjpediatr.org/article/view/5019 |
| spellingShingle | Mukadder Ayşe Selimoğlu Vildan Ertekin Hamza Karabiber Ahmet Turgut Nesrin Gürsan Treatment results of chronic hepatitis B in children: a retrospective study The Turkish Journal of Pediatrics |
| title | Treatment results of chronic hepatitis B in children: a retrospective study |
| title_full | Treatment results of chronic hepatitis B in children: a retrospective study |
| title_fullStr | Treatment results of chronic hepatitis B in children: a retrospective study |
| title_full_unstemmed | Treatment results of chronic hepatitis B in children: a retrospective study |
| title_short | Treatment results of chronic hepatitis B in children: a retrospective study |
| title_sort | treatment results of chronic hepatitis b in children a retrospective study |
| url | https://turkjpediatr.org/article/view/5019 |
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