A study on the impact of glycemic status on central corneal thickness and intraocular pressure in diabetic patients attending a tertiary care center in central Kerala
Purpose: This study aims to evaluate the central corneal thickness (CCT), intraocular pressure (IOP), and glycemic status in uncontrolled diabetic patients at baseline, 1 week, and 12 weeks, and to examine the relationship between changes in CCT and IOP with fluctuations in glycemic status. Methods:...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Kerala Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/kjo.kjo_35_24 |
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| Summary: | Purpose:
This study aims to evaluate the central corneal thickness (CCT), intraocular pressure (IOP), and glycemic status in uncontrolled diabetic patients at baseline, 1 week, and 12 weeks, and to examine the relationship between changes in CCT and IOP with fluctuations in glycemic status.
Methods:
Diabetic individuals with hyperglycemia, defined as having postprandial blood sugar (PPBS) levels exceeding 200 mg/dl and glycated hemoglobin (HbA1c) greater than 7%, aged between 18 and 80 years, were enrolled in the study. Glycemic status was evaluated through fasting blood sugar (FBS), PPBS, and HbA1c levels. Participants underwent a comprehensive ocular examination, CCT measurement utilizing Carl Zeiss Spectral Domain Anterior Segment Optical Coherence Tomography (AS-OCT), and IOP measurement using Goldmann Applanation Tonometer. Participants were advised to pursue treatment for glycemic management. Follow-up evaluations were conducted at 1 week and at 12 weeks.
Results:
The average CCT was 560.9+/−22 µm during the initial visit, 560.7+/−22 µm at 1 week, and 539.0+/−61.1 µm at 12 weeks (p 0.008). The mean IOP was 17.2+/−2.7 mm Hg at the first visit, 17.1+/−2.7 mm Hg at 1 week, and 15.3+/−2.6 mm Hg at 12 weeks (P 0.01).
Conclusion:
Achieving optimal glycemic control in diabetic patients leads to a significant reduction in CCT and IOP. Stable euglycemia as evidenced by HbA1c at 3 months is a determinant of reliable IOP measurement. Hence we recommend that healthcare providers should look into the glycemic status, specifically HbA1C once in 3 months during glaucoma related decision making in diabetic patients. |
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| ISSN: | 0976-6677 |