Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study
Transcranial alternating current stimulation (tACS) at 5-Hz to the right hemisphere can alleviate anxiety symptoms. We aimed to explore the connectivity changes following the treatment. We collected electroencephalography (EEG) data from 24 participants with anxiety disorders before and after the tA...
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AIMS Press
2024-10-01
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| Series: | AIMS Neuroscience |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/Neuroscience.2024026 |
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| author | Tien-Wen Lee Gerald Tramontano |
| author_facet | Tien-Wen Lee Gerald Tramontano |
| author_sort | Tien-Wen Lee |
| collection | DOAJ |
| description | Transcranial alternating current stimulation (tACS) at 5-Hz to the right hemisphere can alleviate anxiety symptoms. We aimed to explore the connectivity changes following the treatment. We collected electroencephalography (EEG) data from 24 participants with anxiety disorders before and after the tACS treatment during a single session. Electric stimulation was applied over the right hemisphere, with 1.0 mA at F4, 1.0 mA at P4, and 2.0 mA at T8, following the 10-10 EEG convention. With eLORETA, the scalp signals were transformed into the cortex's current source density. We assessed the connectivity changes at theta frequency between the centers of Brodmann area (BA) 6/8 (frontal), BA 39/40 (parietal), and BA 21 (middle temporal). Functional connectivity was indicated by lagged coherences and lagged phase synchronization. Paired t-tests were used to quantify the differences statistically. We observed enhanced lagged phase synchronization at theta frequency between the frontal and parietal regions (P = 0.002) and between the parietal and temporal regions (P = 0.005) after Bonferroni correction. Applying tACS 5-Hz over the right hemisphere enhanced inter-regional interaction, which was spectrum-specific and mainly mediated by phase rather than power synchrony. The potential neural mechanisms are discussed. |
| format | Article |
| id | doaj-art-1f847f27d90a4aad9835754ee58abb04 |
| institution | Kabale University |
| issn | 2373-7972 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | AIMS Press |
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| series | AIMS Neuroscience |
| spelling | doaj-art-1f847f27d90a4aad9835754ee58abb042025-01-24T01:29:33ZengAIMS PressAIMS Neuroscience2373-79722024-10-0111443944810.3934/Neuroscience.2024026Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG studyTien-Wen Lee0Gerald Tramontano1The NeuroCognitive Institute (NCI) Clinical Research Foundation, NJ 07856, USThe NeuroCognitive Institute (NCI) Clinical Research Foundation, NJ 07856, USTranscranial alternating current stimulation (tACS) at 5-Hz to the right hemisphere can alleviate anxiety symptoms. We aimed to explore the connectivity changes following the treatment. We collected electroencephalography (EEG) data from 24 participants with anxiety disorders before and after the tACS treatment during a single session. Electric stimulation was applied over the right hemisphere, with 1.0 mA at F4, 1.0 mA at P4, and 2.0 mA at T8, following the 10-10 EEG convention. With eLORETA, the scalp signals were transformed into the cortex's current source density. We assessed the connectivity changes at theta frequency between the centers of Brodmann area (BA) 6/8 (frontal), BA 39/40 (parietal), and BA 21 (middle temporal). Functional connectivity was indicated by lagged coherences and lagged phase synchronization. Paired t-tests were used to quantify the differences statistically. We observed enhanced lagged phase synchronization at theta frequency between the frontal and parietal regions (P = 0.002) and between the parietal and temporal regions (P = 0.005) after Bonferroni correction. Applying tACS 5-Hz over the right hemisphere enhanced inter-regional interaction, which was spectrum-specific and mainly mediated by phase rather than power synchrony. The potential neural mechanisms are discussed.https://www.aimspress.com/article/doi/10.3934/Neuroscience.2024026transcranial alternating current stimulation (tacs)transcranial electrical stimulation (tes)electroencephalography (eeg)exact low-resolution electromagnetic tomography (eloreta)coherencephase synchronizationconnectivity |
| spellingShingle | Tien-Wen Lee Gerald Tramontano Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study AIMS Neuroscience transcranial alternating current stimulation (tacs) transcranial electrical stimulation (tes) electroencephalography (eeg) exact low-resolution electromagnetic tomography (eloreta) coherence phase synchronization connectivity |
| title | Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study |
| title_full | Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study |
| title_fullStr | Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study |
| title_full_unstemmed | Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study |
| title_short | Connectivity changes following transcranial alternating current stimulation at 5-Hz: an EEG study |
| title_sort | connectivity changes following transcranial alternating current stimulation at 5 hz an eeg study |
| topic | transcranial alternating current stimulation (tacs) transcranial electrical stimulation (tes) electroencephalography (eeg) exact low-resolution electromagnetic tomography (eloreta) coherence phase synchronization connectivity |
| url | https://www.aimspress.com/article/doi/10.3934/Neuroscience.2024026 |
| work_keys_str_mv | AT tienwenlee connectivitychangesfollowingtranscranialalternatingcurrentstimulationat5hzaneegstudy AT geraldtramontano connectivitychangesfollowingtranscranialalternatingcurrentstimulationat5hzaneegstudy |