MicroRNAs as Novel Regulators of Neuroinflammation
MicroRNAs are relatively recently discovered class of small noncoding RNAs, which function as important regulators of gene expression. They fine-tune protein expression either by translational inhibition or mRNA degradation. MicroRNAs act as regulators of diverse cellular processes, such as cell dif...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/172351 |
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| _version_ | 1850230781865099264 |
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| author | Dominika Justyna Ksiazek-Winiarek Magdalena Justyna Kacperska Andrzej Glabinski |
| author_facet | Dominika Justyna Ksiazek-Winiarek Magdalena Justyna Kacperska Andrzej Glabinski |
| author_sort | Dominika Justyna Ksiazek-Winiarek |
| collection | DOAJ |
| description | MicroRNAs are relatively recently discovered class of small noncoding RNAs, which function as important regulators of gene expression. They fine-tune protein expression either by translational inhibition or mRNA degradation. MicroRNAs act as regulators of diverse cellular processes, such as cell differentiation, proliferation, and apoptosis. Their defective biogenesis or function has been identified in various pathological conditions, like inflammation, neurodegeneration, or autoimmunity. Multiple sclerosis is one of the predominated debilitating neurological diseases affecting mainly young adults. It is a multifactorial disorder of as yet unknown aetiology. As far, it is suggested that interplay between genetic and environmental factors is responsible for MS pathogenesis. The role of microRNAs in this pathology is now extensively studied. Here, we want to review the current knowledge of microRNAs role in multiple sclerosis. |
| format | Article |
| id | doaj-art-1f7e502ee5d24b31b0fbeae9ec39be1c |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1f7e502ee5d24b31b0fbeae9ec39be1c2025-08-20T02:03:46ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/172351172351MicroRNAs as Novel Regulators of NeuroinflammationDominika Justyna Ksiazek-Winiarek0Magdalena Justyna Kacperska1Andrzej Glabinski2Department of Neurology, Epileptology and Stroke, Medical University of Lodz, Zeromskiego Street 113, 90-549 Lodz, PolandDepartment of Neurology, Epileptology and Stroke, Medical University of Lodz, Zeromskiego Street 113, 90-549 Lodz, PolandDepartment of Neurology, Epileptology and Stroke, Medical University of Lodz, Zeromskiego Street 113, 90-549 Lodz, PolandMicroRNAs are relatively recently discovered class of small noncoding RNAs, which function as important regulators of gene expression. They fine-tune protein expression either by translational inhibition or mRNA degradation. MicroRNAs act as regulators of diverse cellular processes, such as cell differentiation, proliferation, and apoptosis. Their defective biogenesis or function has been identified in various pathological conditions, like inflammation, neurodegeneration, or autoimmunity. Multiple sclerosis is one of the predominated debilitating neurological diseases affecting mainly young adults. It is a multifactorial disorder of as yet unknown aetiology. As far, it is suggested that interplay between genetic and environmental factors is responsible for MS pathogenesis. The role of microRNAs in this pathology is now extensively studied. Here, we want to review the current knowledge of microRNAs role in multiple sclerosis.http://dx.doi.org/10.1155/2013/172351 |
| spellingShingle | Dominika Justyna Ksiazek-Winiarek Magdalena Justyna Kacperska Andrzej Glabinski MicroRNAs as Novel Regulators of Neuroinflammation Mediators of Inflammation |
| title | MicroRNAs as Novel Regulators of Neuroinflammation |
| title_full | MicroRNAs as Novel Regulators of Neuroinflammation |
| title_fullStr | MicroRNAs as Novel Regulators of Neuroinflammation |
| title_full_unstemmed | MicroRNAs as Novel Regulators of Neuroinflammation |
| title_short | MicroRNAs as Novel Regulators of Neuroinflammation |
| title_sort | micrornas as novel regulators of neuroinflammation |
| url | http://dx.doi.org/10.1155/2013/172351 |
| work_keys_str_mv | AT dominikajustynaksiazekwiniarek micrornasasnovelregulatorsofneuroinflammation AT magdalenajustynakacperska micrornasasnovelregulatorsofneuroinflammation AT andrzejglabinski micrornasasnovelregulatorsofneuroinflammation |