Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium
Osteoarthritis (OA) is characterized mainly by articular cartilage loss, subchondral osteosclerosis, and chronic inflammation and involves multiple types of cellular dysfunction and tissue lesions. The rapid development of nanotechnology and materials science has contributed to the application of bi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2024-12-01
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| Series: | Advanced NanoBiomed Research |
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| Online Access: | https://doi.org/10.1002/anbr.202400029 |
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| author | Xiaoshan Gong Hao Tang Jingjin Dai Guoqiang Wang Shiwu Dong |
| author_facet | Xiaoshan Gong Hao Tang Jingjin Dai Guoqiang Wang Shiwu Dong |
| author_sort | Xiaoshan Gong |
| collection | DOAJ |
| description | Osteoarthritis (OA) is characterized mainly by articular cartilage loss, subchondral osteosclerosis, and chronic inflammation and involves multiple types of cellular dysfunction and tissue lesions. The rapid development of nanotechnology and materials science has contributed to the application of biomimetic nanomaterials in the biomedical field. By optimizing the composition, hardness, porosity, and drug loading of biomimetic nanomaterials, their unique physicochemical properties drive potential applications in bone repair. This article reviews the present understanding of the physiopathological mechanism and clinical treatment drawbacks of OA and summarizes various types of biomimetic nanomaterials for OA that target lesion sites, such as cartilage, subchondral bone, and synovium, through simulation of the physiological structure and microenvironment. Eventually, the challenges and prospects for the clinical translation of biomimetic nanomaterials are further discussed, with the goal of accessing an effective approach for OA treatment. |
| format | Article |
| id | doaj-art-1f7cd882134f486c936f7a5f2fd8d270 |
| institution | DOAJ |
| issn | 2699-9307 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj-art-1f7cd882134f486c936f7a5f2fd8d2702025-08-20T02:50:23ZengWiley-VCHAdvanced NanoBiomed Research2699-93072024-12-01412n/an/a10.1002/anbr.202400029Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and SynoviumXiaoshan Gong0Hao Tang1Jingjin Dai2Guoqiang Wang3Shiwu Dong4Department of Biomedical Materials Science College of Biomedical Engineering Third Military Medical University Chongqing 400038 ChinaDepartment of Biomedical Materials Science College of Biomedical Engineering Third Military Medical University Chongqing 400038 ChinaDepartment of Biomedical Materials Science College of Biomedical Engineering Third Military Medical University Chongqing 400038 ChinaDepartment of Psychology Fourth Military Medical University Xi'an 710032 ChinaDepartment of Biomedical Materials Science College of Biomedical Engineering Third Military Medical University Chongqing 400038 ChinaOsteoarthritis (OA) is characterized mainly by articular cartilage loss, subchondral osteosclerosis, and chronic inflammation and involves multiple types of cellular dysfunction and tissue lesions. The rapid development of nanotechnology and materials science has contributed to the application of biomimetic nanomaterials in the biomedical field. By optimizing the composition, hardness, porosity, and drug loading of biomimetic nanomaterials, their unique physicochemical properties drive potential applications in bone repair. This article reviews the present understanding of the physiopathological mechanism and clinical treatment drawbacks of OA and summarizes various types of biomimetic nanomaterials for OA that target lesion sites, such as cartilage, subchondral bone, and synovium, through simulation of the physiological structure and microenvironment. Eventually, the challenges and prospects for the clinical translation of biomimetic nanomaterials are further discussed, with the goal of accessing an effective approach for OA treatment.https://doi.org/10.1002/anbr.202400029cartilagenanobimetic materialsosteoarthritissubchondral bonesynovium |
| spellingShingle | Xiaoshan Gong Hao Tang Jingjin Dai Guoqiang Wang Shiwu Dong Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium Advanced NanoBiomed Research cartilage nanobimetic materials osteoarthritis subchondral bone synovium |
| title | Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium |
| title_full | Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium |
| title_fullStr | Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium |
| title_full_unstemmed | Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium |
| title_short | Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium |
| title_sort | biomimetic nanomaterials for osteoarthritis treatment targeting cartilage subchondral bone and synovium |
| topic | cartilage nanobimetic materials osteoarthritis subchondral bone synovium |
| url | https://doi.org/10.1002/anbr.202400029 |
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