Early boosting of p38 MAPK signaling pathway by lycorine hydrochloride potently inhibits PRRSV proliferation in primary and established cells

Early boosting of p38 MAPK signaling pathway by lycorine hydrochloride potently inhibits PRRSV proliferation in primary and established cells

Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous economic losses in the swine industry since emerging in the late 1980s. Although vaccination has been widely used to control PRRS epidemics in Chinese pig farms, they provided limited protection against PRRSV transmiss...

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Bibliographic Details
Main Authors: Lizhan Su, Zhening Zhang, Siqi Zhang, Jiajing He, Yaoqi Chen, Guohong Wu, Zhiying Zhang, Weisan Chen, Mingxin Zhang, Jianxin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
Subjects:
porcine reproductive and respiratory syndrome virus (PRRSV)
lycorine hydrochloride (LH)
p38 mitogen-activated protein kinase (p38 MAPK)
NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3)
interleukin-1β (IL-1β)
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1664973/full
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