The relationship between bipolar disorder and breast cancer: a two-sample Mendelian randomization study
Objective To explore the causal relationship between bipolar disorder and breast cancer and its subtypes (estrogen receptor-positive and estrogen receptor-negative breast cancer).Methods Using genome-wide association data of bipolar disorder and breast cancer, a two-sample Mendelian randomization an...
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| Format: | Article |
| Language: | zho |
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Editorial Office of New Medicine
2025-02-01
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| Series: | Yixue xinzhi zazhi |
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| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2502/fM16xPp5BbFLOBCNFglcQpaqwKwHTYHM5OcawT56.pdf |
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| _version_ | 1850189539156426752 |
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| author | MA Tingting ZHAO Xiaoli GUO Xiaolong FAN Chunling ZHANG Yinfang CAO Juan SONG Peng FAN Jingchun |
| author_facet | MA Tingting ZHAO Xiaoli GUO Xiaolong FAN Chunling ZHANG Yinfang CAO Juan SONG Peng FAN Jingchun |
| author_sort | MA Tingting |
| collection | DOAJ |
| description | Objective To explore the causal relationship between bipolar disorder and breast cancer and its subtypes (estrogen receptor-positive and estrogen receptor-negative breast cancer).Methods Using genome-wide association data of bipolar disorder and breast cancer, a two-sample Mendelian randomization analysis was performed to identify single nucleotide polymorphisms associated with bipolar disorder and explore their association with breast cancer. The inverse-variance weighting (IVW) method served as the primary research approach, while MR Egger, weighted median estimator, and weighted mode were employed as supplementary methods. Sensitivity analyses were performed to assess heterogeneity and pleiotropy.Results The IVW analysis revealed no causal relationship between bipolar disorder and overall breast cancer [OR=1.04, 95%CI(0.98, 1.12)], nor with its two subtypes (P>0.05). The supplementary methods were consistent with the IVW findings. Sensitivity analyses indicated that the results were reliable.Conclusion There is no causal relationship between bipolar disorder and the risk of developing overall breast cancer, nor is there support for a causal relationship with a specific subtype of breast cancer. |
| format | Article |
| id | doaj-art-1f77c404cb394583bdfd4f1ae5e536ea |
| institution | OA Journals |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-1f77c404cb394583bdfd4f1ae5e536ea2025-08-20T02:15:36ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112025-02-0135216116710.12173/j.issn.1004-5511.2024080826599The relationship between bipolar disorder and breast cancer: a two-sample Mendelian randomization studyMA TingtingZHAO XiaoliGUO XiaolongFAN ChunlingZHANG YinfangCAO JuanSONG PengFAN JingchunObjective To explore the causal relationship between bipolar disorder and breast cancer and its subtypes (estrogen receptor-positive and estrogen receptor-negative breast cancer).Methods Using genome-wide association data of bipolar disorder and breast cancer, a two-sample Mendelian randomization analysis was performed to identify single nucleotide polymorphisms associated with bipolar disorder and explore their association with breast cancer. The inverse-variance weighting (IVW) method served as the primary research approach, while MR Egger, weighted median estimator, and weighted mode were employed as supplementary methods. Sensitivity analyses were performed to assess heterogeneity and pleiotropy.Results The IVW analysis revealed no causal relationship between bipolar disorder and overall breast cancer [OR=1.04, 95%CI(0.98, 1.12)], nor with its two subtypes (P>0.05). The supplementary methods were consistent with the IVW findings. Sensitivity analyses indicated that the results were reliable.Conclusion There is no causal relationship between bipolar disorder and the risk of developing overall breast cancer, nor is there support for a causal relationship with a specific subtype of breast cancer.https://yxxz.whuznhmedj.com/futureApi/storage/attach/2502/fM16xPp5BbFLOBCNFglcQpaqwKwHTYHM5OcawT56.pdfbipolar disorderbreast cancermendelian randomizationestrogen receptor-positive breast cancerestrogen receptor-negative breast cancer |
| spellingShingle | MA Tingting ZHAO Xiaoli GUO Xiaolong FAN Chunling ZHANG Yinfang CAO Juan SONG Peng FAN Jingchun The relationship between bipolar disorder and breast cancer: a two-sample Mendelian randomization study Yixue xinzhi zazhi bipolar disorder breast cancer mendelian randomization estrogen receptor-positive breast cancer estrogen receptor-negative breast cancer |
| title | The relationship between bipolar disorder and breast cancer: a two-sample Mendelian randomization study |
| title_full | The relationship between bipolar disorder and breast cancer: a two-sample Mendelian randomization study |
| title_fullStr | The relationship between bipolar disorder and breast cancer: a two-sample Mendelian randomization study |
| title_full_unstemmed | The relationship between bipolar disorder and breast cancer: a two-sample Mendelian randomization study |
| title_short | The relationship between bipolar disorder and breast cancer: a two-sample Mendelian randomization study |
| title_sort | relationship between bipolar disorder and breast cancer a two sample mendelian randomization study |
| topic | bipolar disorder breast cancer mendelian randomization estrogen receptor-positive breast cancer estrogen receptor-negative breast cancer |
| url | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2502/fM16xPp5BbFLOBCNFglcQpaqwKwHTYHM5OcawT56.pdf |
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