Aftermath of Apixaban: Atypical Anticoagulation Aftereffect
An elderly man with prostate cancer and a deep vein thrombosis (DVT) of the lower extremity diagnosed 12 days ago on apixaban presented with a new-onset palpable rash on both of his legs. Extensive laboratory workup was largely unremarkable, except for multiple skin punch biopsies revealing depositi...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2022/6221640 |
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| author | Bhesh Karki Louis Costanzo Sameer Joshi Aleksey Fiksman |
| author_facet | Bhesh Karki Louis Costanzo Sameer Joshi Aleksey Fiksman |
| author_sort | Bhesh Karki |
| collection | DOAJ |
| description | An elderly man with prostate cancer and a deep vein thrombosis (DVT) of the lower extremity diagnosed 12 days ago on apixaban presented with a new-onset palpable rash on both of his legs. Extensive laboratory workup was largely unremarkable, except for multiple skin punch biopsies revealing deposition of immunoglobulin A (IgA) in the superficial blood vessels with infiltration of leukocytes, concerning for a small vessel vasculitis. Given the temporal association along with the negative workup, the rash was attributed to apixaban, and the anticoagulation regimen was switched to dabigatran. At a 2-week follow-up visit, the patient was asymptomatic and tolerating dabigatran without any adverse events. |
| format | Article |
| id | doaj-art-1f706c05401949d1801edd81a8ee9be8 |
| institution | Kabale University |
| issn | 2090-6897 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-1f706c05401949d1801edd81a8ee9be82025-02-03T01:07:56ZengWileyCase Reports in Rheumatology2090-68972022-01-01202210.1155/2022/6221640Aftermath of Apixaban: Atypical Anticoagulation AftereffectBhesh Karki0Louis Costanzo1Sameer Joshi2Aleksey Fiksman3Department of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicineBrooklyn VA Medical CenterAn elderly man with prostate cancer and a deep vein thrombosis (DVT) of the lower extremity diagnosed 12 days ago on apixaban presented with a new-onset palpable rash on both of his legs. Extensive laboratory workup was largely unremarkable, except for multiple skin punch biopsies revealing deposition of immunoglobulin A (IgA) in the superficial blood vessels with infiltration of leukocytes, concerning for a small vessel vasculitis. Given the temporal association along with the negative workup, the rash was attributed to apixaban, and the anticoagulation regimen was switched to dabigatran. At a 2-week follow-up visit, the patient was asymptomatic and tolerating dabigatran without any adverse events.http://dx.doi.org/10.1155/2022/6221640 |
| spellingShingle | Bhesh Karki Louis Costanzo Sameer Joshi Aleksey Fiksman Aftermath of Apixaban: Atypical Anticoagulation Aftereffect Case Reports in Rheumatology |
| title | Aftermath of Apixaban: Atypical Anticoagulation Aftereffect |
| title_full | Aftermath of Apixaban: Atypical Anticoagulation Aftereffect |
| title_fullStr | Aftermath of Apixaban: Atypical Anticoagulation Aftereffect |
| title_full_unstemmed | Aftermath of Apixaban: Atypical Anticoagulation Aftereffect |
| title_short | Aftermath of Apixaban: Atypical Anticoagulation Aftereffect |
| title_sort | aftermath of apixaban atypical anticoagulation aftereffect |
| url | http://dx.doi.org/10.1155/2022/6221640 |
| work_keys_str_mv | AT bheshkarki aftermathofapixabanatypicalanticoagulationaftereffect AT louiscostanzo aftermathofapixabanatypicalanticoagulationaftereffect AT sameerjoshi aftermathofapixabanatypicalanticoagulationaftereffect AT alekseyfiksman aftermathofapixabanatypicalanticoagulationaftereffect |