Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration
Marrow adipose tissue (MAT) is a unique fat depot in the bone marrow and exhibits close relationship with hematopoiesis and bone homeostasis. MAT is distinct from peripheral adipose tissue in respect of its heterogeneous origin, site-specific distribution, and complex and perplexing function. Though...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/7098456 |
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| _version_ | 1832552622681227264 |
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| author | Qiwen Li Yunshu Wu Ning Kang |
| author_facet | Qiwen Li Yunshu Wu Ning Kang |
| author_sort | Qiwen Li |
| collection | DOAJ |
| description | Marrow adipose tissue (MAT) is a unique fat depot in the bone marrow and exhibits close relationship with hematopoiesis and bone homeostasis. MAT is distinct from peripheral adipose tissue in respect of its heterogeneous origin, site-specific distribution, and complex and perplexing function. Though MAT is indicated to function in hematopoiesis, skeletal remodeling, and energy metabolism, its explicit characterization still requires further research. In this review, we highlight recent advancement made in MAT regarding the origin and distribution of MAT, the local interaction with bone homeostasis and hematopoietic niche, the systemic endocrine regulation of metabolism, and MAT-based strategies to enhance bone formation. |
| format | Article |
| id | doaj-art-1f6f64b9e39f43e5b08e1875fab77462 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-1f6f64b9e39f43e5b08e1875fab774622025-02-03T05:58:11ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/70984567098456Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and RegenerationQiwen Li0Yunshu Wu1Ning Kang2State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaDepartment of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaMarrow adipose tissue (MAT) is a unique fat depot in the bone marrow and exhibits close relationship with hematopoiesis and bone homeostasis. MAT is distinct from peripheral adipose tissue in respect of its heterogeneous origin, site-specific distribution, and complex and perplexing function. Though MAT is indicated to function in hematopoiesis, skeletal remodeling, and energy metabolism, its explicit characterization still requires further research. In this review, we highlight recent advancement made in MAT regarding the origin and distribution of MAT, the local interaction with bone homeostasis and hematopoietic niche, the systemic endocrine regulation of metabolism, and MAT-based strategies to enhance bone formation.http://dx.doi.org/10.1155/2018/7098456 |
| spellingShingle | Qiwen Li Yunshu Wu Ning Kang Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration Stem Cells International |
| title | Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration |
| title_full | Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration |
| title_fullStr | Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration |
| title_full_unstemmed | Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration |
| title_short | Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration |
| title_sort | marrow adipose tissue its origin function and regulation in bone remodeling and regeneration |
| url | http://dx.doi.org/10.1155/2018/7098456 |
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