T cell metabolism in kidney immune homeostasis
Kidney immune homeostasis is intricately linked to T cells. Inappropriate differentiation, activation, and effector functions of T cells lead to a spectrum of kidney disease. While executing immune functions, T cells undergo a series of metabolic rewiring to meet the rapid energy demand. The key enz...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1498808/full |
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| author | Zikang Liu Zikang Liu Binbin Dai Binbin Dai Jiwen Bao Jiwen Bao Yangbin Pan Yangbin Pan |
| author_facet | Zikang Liu Zikang Liu Binbin Dai Binbin Dai Jiwen Bao Jiwen Bao Yangbin Pan Yangbin Pan |
| author_sort | Zikang Liu |
| collection | DOAJ |
| description | Kidney immune homeostasis is intricately linked to T cells. Inappropriate differentiation, activation, and effector functions of T cells lead to a spectrum of kidney disease. While executing immune functions, T cells undergo a series of metabolic rewiring to meet the rapid energy demand. The key enzymes and metabolites involved in T cell metabolism metabolically and epigenetically modulate T cells' differentiation, activation, and effector functions, thereby being capable of modulating kidney immune homeostasis. In this review, we first summarize the latest advancements in T cell immunometabolism. Second, we outline the alterations in the renal microenvironment under certain kidney disease conditions. Ultimately, we highlight the metabolic modulation of T cells within kidney immune homeostasis, which may shed light on new strategies for treating kidney disease. |
| format | Article |
| id | doaj-art-1f64fea6781a42e482a238846e825cf0 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1f64fea6781a42e482a238846e825cf02025-08-20T01:56:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14988081498808T cell metabolism in kidney immune homeostasisZikang Liu0Zikang Liu1Binbin Dai2Binbin Dai3Jiwen Bao4Jiwen Bao5Yangbin Pan6Yangbin Pan7Department of Nephrology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Nephrology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Nephrology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Nephrology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaKidney immune homeostasis is intricately linked to T cells. Inappropriate differentiation, activation, and effector functions of T cells lead to a spectrum of kidney disease. While executing immune functions, T cells undergo a series of metabolic rewiring to meet the rapid energy demand. The key enzymes and metabolites involved in T cell metabolism metabolically and epigenetically modulate T cells' differentiation, activation, and effector functions, thereby being capable of modulating kidney immune homeostasis. In this review, we first summarize the latest advancements in T cell immunometabolism. Second, we outline the alterations in the renal microenvironment under certain kidney disease conditions. Ultimately, we highlight the metabolic modulation of T cells within kidney immune homeostasis, which may shed light on new strategies for treating kidney disease.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1498808/fullT cellcellular metabolismkidney diseasemicroenvironmentimmune homeostasis |
| spellingShingle | Zikang Liu Zikang Liu Binbin Dai Binbin Dai Jiwen Bao Jiwen Bao Yangbin Pan Yangbin Pan T cell metabolism in kidney immune homeostasis Frontiers in Immunology T cell cellular metabolism kidney disease microenvironment immune homeostasis |
| title | T cell metabolism in kidney immune homeostasis |
| title_full | T cell metabolism in kidney immune homeostasis |
| title_fullStr | T cell metabolism in kidney immune homeostasis |
| title_full_unstemmed | T cell metabolism in kidney immune homeostasis |
| title_short | T cell metabolism in kidney immune homeostasis |
| title_sort | t cell metabolism in kidney immune homeostasis |
| topic | T cell cellular metabolism kidney disease microenvironment immune homeostasis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1498808/full |
| work_keys_str_mv | AT zikangliu tcellmetabolisminkidneyimmunehomeostasis AT zikangliu tcellmetabolisminkidneyimmunehomeostasis AT binbindai tcellmetabolisminkidneyimmunehomeostasis AT binbindai tcellmetabolisminkidneyimmunehomeostasis AT jiwenbao tcellmetabolisminkidneyimmunehomeostasis AT jiwenbao tcellmetabolisminkidneyimmunehomeostasis AT yangbinpan tcellmetabolisminkidneyimmunehomeostasis AT yangbinpan tcellmetabolisminkidneyimmunehomeostasis |