Apoptosis-inducing proteins with reduced expression in breast cancer: A review article
Breast cancer is considered one of the most abundant malignancies with high morbidity and mortality. Traditional cancer treatments possess various weaknesses, including a lack of specificity and numerous side effects. Novel cancer therapies aim to overcome the shortcomings of traditional therapies a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Biochemistry and Biophysics Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580825000184 |
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| author | Mohammad Mehdi Khaleghi Faezeh Rouhi Kourosh Eslami Fatemeh Shafiee |
| author_facet | Mohammad Mehdi Khaleghi Faezeh Rouhi Kourosh Eslami Fatemeh Shafiee |
| author_sort | Mohammad Mehdi Khaleghi |
| collection | DOAJ |
| description | Breast cancer is considered one of the most abundant malignancies with high morbidity and mortality. Traditional cancer treatments possess various weaknesses, including a lack of specificity and numerous side effects. Novel cancer therapies aim to overcome the shortcomings of traditional therapies and offer more efficient and safe treatments. Designing and identifying novel proteins that can practically and specifically inhibit tumors by inducing apoptosis can interest researchers in this field. This review discusses recent studies on the use of four promising proteins, KAI1, Apoptin, BIF-1, and DFF-40, for breast cancer treatment. This study also focuses on alterations in the expression of the androgenic proteins and novel strategies for better penetration and delivery of these proteins. Lastly, prospects for protein-based targeted cancer therapy and future studies in this field are highlighted. |
| format | Article |
| id | doaj-art-1f59040ce74d4469a2fd77da9b49bb83 |
| institution | Kabale University |
| issn | 2405-5808 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj-art-1f59040ce74d4469a2fd77da9b49bb832025-02-07T04:47:51ZengElsevierBiochemistry and Biophysics Reports2405-58082025-03-0141101931Apoptosis-inducing proteins with reduced expression in breast cancer: A review articleMohammad Mehdi Khaleghi0Faezeh Rouhi1Kourosh Eslami2Fatemeh Shafiee3Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; Corresponding author. School of Pharmacy and Pharmaceutical Sciences. Isfahan University of Medical Sciences, Hezar Jarib Ave. Isfahan, Iran.Breast cancer is considered one of the most abundant malignancies with high morbidity and mortality. Traditional cancer treatments possess various weaknesses, including a lack of specificity and numerous side effects. Novel cancer therapies aim to overcome the shortcomings of traditional therapies and offer more efficient and safe treatments. Designing and identifying novel proteins that can practically and specifically inhibit tumors by inducing apoptosis can interest researchers in this field. This review discusses recent studies on the use of four promising proteins, KAI1, Apoptin, BIF-1, and DFF-40, for breast cancer treatment. This study also focuses on alterations in the expression of the androgenic proteins and novel strategies for better penetration and delivery of these proteins. Lastly, prospects for protein-based targeted cancer therapy and future studies in this field are highlighted.http://www.sciencedirect.com/science/article/pii/S2405580825000184ApoptosisBreast neoplasmsDown-regulationGene expressionProteins |
| spellingShingle | Mohammad Mehdi Khaleghi Faezeh Rouhi Kourosh Eslami Fatemeh Shafiee Apoptosis-inducing proteins with reduced expression in breast cancer: A review article Biochemistry and Biophysics Reports Apoptosis Breast neoplasms Down-regulation Gene expression Proteins |
| title | Apoptosis-inducing proteins with reduced expression in breast cancer: A review article |
| title_full | Apoptosis-inducing proteins with reduced expression in breast cancer: A review article |
| title_fullStr | Apoptosis-inducing proteins with reduced expression in breast cancer: A review article |
| title_full_unstemmed | Apoptosis-inducing proteins with reduced expression in breast cancer: A review article |
| title_short | Apoptosis-inducing proteins with reduced expression in breast cancer: A review article |
| title_sort | apoptosis inducing proteins with reduced expression in breast cancer a review article |
| topic | Apoptosis Breast neoplasms Down-regulation Gene expression Proteins |
| url | http://www.sciencedirect.com/science/article/pii/S2405580825000184 |
| work_keys_str_mv | AT mohammadmehdikhaleghi apoptosisinducingproteinswithreducedexpressioninbreastcancerareviewarticle AT faezehrouhi apoptosisinducingproteinswithreducedexpressioninbreastcancerareviewarticle AT kourosheslami apoptosisinducingproteinswithreducedexpressioninbreastcancerareviewarticle AT fatemehshafiee apoptosisinducingproteinswithreducedexpressioninbreastcancerareviewarticle |