Generation and Characterization of a Human-Derived iPSC line from a female child with First-Episode of sporadic schizophrenia
Schizophrenia is a highly heritable neurodevelopmental disorder. In this study, peripheral blood mononuclear cells (PBMCs) were obtained from a female child diagnosed with first-episode of sporadic schizophrenia. Induced pluripotent stem cells (iPSCs) were generated by introducing the reprogramming...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
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| Series: | Stem Cell Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506125000637 |
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| Summary: | Schizophrenia is a highly heritable neurodevelopmental disorder. In this study, peripheral blood mononuclear cells (PBMCs) were obtained from a female child diagnosed with first-episode of sporadic schizophrenia. Induced pluripotent stem cells (iPSCs) were generated by introducing the reprogramming factors OCT4, SOX2, NANOG, LIN28, c-MYC, KLF4, and SV40LT. The iPSC line was confirmed through karyotyping and the expression of key pluripotency markers. These cells demonstrated the ability to differentiate into all three germ layers in vivo. |
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| ISSN: | 1873-5061 |