Impact of PD-1 and PD-L1 expression on treatment outcomes in newly diagnosed acute myeloid leukemia patients
High expression of immune checkpoint markers may leukemic cells to evade the immune system in AML. This study aimed to investigate the relationship between PD-1/PD-L1 expression and treatment outcomes in AML patients.. The study included 21 patients and 18 healthy volunteers. Non-responders exhibite...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048925000160 |
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| author | Ugur Calis Merve Aydogan Guldane Cengiz Seval Klara Dalva Selami Kocak Toprak |
| author_facet | Ugur Calis Merve Aydogan Guldane Cengiz Seval Klara Dalva Selami Kocak Toprak |
| author_sort | Ugur Calis |
| collection | DOAJ |
| description | High expression of immune checkpoint markers may leukemic cells to evade the immune system in AML. This study aimed to investigate the relationship between PD-1/PD-L1 expression and treatment outcomes in AML patients.. The study included 21 patients and 18 healthy volunteers. Non-responders exhibited significantly higher PD-1 expression (MFI) in CD3+ and CD4+ T cells. At the time of diagnosis, bone marrow samples from patients exhibited a significantly higher proportion of PD-1 expression in CD3+, CD4+, and CD8+ T lymphocytes than peripheral blood samples. The results revealed an association between PD-1/PD-L1 expression and clinical traits in newly diagnosed AML patients. |
| format | Article |
| id | doaj-art-1f50f4335d964bb28f44e3fa8db64516 |
| institution | OA Journals |
| issn | 2213-0489 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj-art-1f50f4335d964bb28f44e3fa8db645162025-08-20T02:37:06ZengElsevierLeukemia Research Reports2213-04892025-01-012310051410.1016/j.lrr.2025.100514Impact of PD-1 and PD-L1 expression on treatment outcomes in newly diagnosed acute myeloid leukemia patientsUgur Calis0Merve Aydogan1Guldane Cengiz Seval2Klara Dalva3Selami Kocak Toprak4Department of Internal Medicine, Ankara University, Ankara, TurkeyDepartment of Hematology, Ankara University, Ankara, TurkeyDepartment of Hematology, Ankara University, Ankara, TurkeyDepartment of Hematology, Ankara University, Ankara, TurkeyDepartment of Hematology, Ankara University, Ankara, Turkey; Corresponding author at: Department of Hematology, Ankara University, Ankara, Turkey.High expression of immune checkpoint markers may leukemic cells to evade the immune system in AML. This study aimed to investigate the relationship between PD-1/PD-L1 expression and treatment outcomes in AML patients.. The study included 21 patients and 18 healthy volunteers. Non-responders exhibited significantly higher PD-1 expression (MFI) in CD3+ and CD4+ T cells. At the time of diagnosis, bone marrow samples from patients exhibited a significantly higher proportion of PD-1 expression in CD3+, CD4+, and CD8+ T lymphocytes than peripheral blood samples. The results revealed an association between PD-1/PD-L1 expression and clinical traits in newly diagnosed AML patients.http://www.sciencedirect.com/science/article/pii/S2213048925000160Acute myeloid LeukemiaAmlPD-1PD-L1Flow cytometry |
| spellingShingle | Ugur Calis Merve Aydogan Guldane Cengiz Seval Klara Dalva Selami Kocak Toprak Impact of PD-1 and PD-L1 expression on treatment outcomes in newly diagnosed acute myeloid leukemia patients Leukemia Research Reports Acute myeloid Leukemia Aml PD-1 PD-L1 Flow cytometry |
| title | Impact of PD-1 and PD-L1 expression on treatment outcomes in newly diagnosed acute myeloid leukemia patients |
| title_full | Impact of PD-1 and PD-L1 expression on treatment outcomes in newly diagnosed acute myeloid leukemia patients |
| title_fullStr | Impact of PD-1 and PD-L1 expression on treatment outcomes in newly diagnosed acute myeloid leukemia patients |
| title_full_unstemmed | Impact of PD-1 and PD-L1 expression on treatment outcomes in newly diagnosed acute myeloid leukemia patients |
| title_short | Impact of PD-1 and PD-L1 expression on treatment outcomes in newly diagnosed acute myeloid leukemia patients |
| title_sort | impact of pd 1 and pd l1 expression on treatment outcomes in newly diagnosed acute myeloid leukemia patients |
| topic | Acute myeloid Leukemia Aml PD-1 PD-L1 Flow cytometry |
| url | http://www.sciencedirect.com/science/article/pii/S2213048925000160 |
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