Prognostic Value of Inflammatory Markers in HBV-Related HCC After Hepatectomy Based on a Clinical Database
Objective Hepatitis B virus (HBV) remains an important risk factor for hepatocellular carcinoma (HCC), and inflammation plays an essential role in tumor development. This study aimed to investigate the impact of inflammatory markers in the postoperative outcomes of patients with HBV-related HCC, pro...
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Investigative Surgery |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/08941939.2025.2475020 |
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| author | Tao Zhou Jiongze Fang Jing Huang Xi Yu Yuying Shan Shengdong Wu Shuqi Mao Caide Lu |
| author_facet | Tao Zhou Jiongze Fang Jing Huang Xi Yu Yuying Shan Shengdong Wu Shuqi Mao Caide Lu |
| author_sort | Tao Zhou |
| collection | DOAJ |
| description | Objective Hepatitis B virus (HBV) remains an important risk factor for hepatocellular carcinoma (HCC), and inflammation plays an essential role in tumor development. This study aimed to investigate the impact of inflammatory markers in the postoperative outcomes of patients with HBV-related HCC, providing valuable prognostic indicators after hepatectomy.Methods We retrospectively analyzed 222 patients with HBV-related HCC after surgical resection. The ROC curve was used to calculate biomarker cutoff values. The Kaplan–Meier method was used to estimate overall survival (OS) and recurrence-free survival (RFS), and univariate and multivariate analyses were used to identify the prognostic factors.Results The Kaplan–Meier analysis revealed that patients with high albumin-bilirubin (ALBI) score, aspartate aminotransferase to platelet ratio index (APRI), and monocyte to lymphocyte ratio (MLR) had worse OS, while those with high ALBI score and MLR had shorter RFS. Multivariate Cox regression analysis identified alpha-fetoprotein >400 ng/mL (hazard ratio [HR]: 2.447, 95% confidence interval [CI]: 1.273–4.706, p = 0.007), alanine aminotransferase (HR: 0.377, 95% CI: 0.171–0.834, p = 0.016), platelet to lymphocyte ratio (HR: 0.385, 95% CI: 0.196–0.755, p = 0.006), systemic inflammatory response index (HR: 1.844, 95% CI: 1.049–3.239, p = 0.033), ALBI score (HR: 1.808, 95% CI: 1.020–3.203, p = 0.043), APRI score (HR: 3.193, 95% CI: 1.662–6.137, p < 0.001), tumor diameter (HR: 1.083, 95% CI: 1.012–1.160, p = 0.022), and portal vein tumor thrombosis (PVTT) (HR: 6.083, 95% CI: 2.774–13.338, p < 0.0001) as independent predictors for OS. MLR (HR: 2.285, 95% CI: 1.290–4.048, p = 0.005) and PVTT (HR: 2.672, 95% CI: 1.280–5.579, p = 0.009) were confirmed as significant prognostic markers of RFS in patients with HBV-related HCC.Conclusions ALBI score, APRI, and MLR are effective prognostic predictors in patients with HBV-related HCC after curative resection. Close monitoring and adjuvant therapies should be considered for high-risk patients. |
| format | Article |
| id | doaj-art-1f484791c47d4173b9a6383e3d57ec61 |
| institution | OA Journals |
| issn | 0894-1939 1521-0553 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Journal of Investigative Surgery |
| spelling | doaj-art-1f484791c47d4173b9a6383e3d57ec612025-08-20T02:15:41ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532025-12-0138110.1080/08941939.2025.2475020Prognostic Value of Inflammatory Markers in HBV-Related HCC After Hepatectomy Based on a Clinical DatabaseTao Zhou0Jiongze Fang1Jing Huang2Xi Yu3Yuying Shan4Shengdong Wu5Shuqi Mao6Caide Lu7Department of Hepatopancreatobiliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaDepartment of Hepatopancreatobiliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaDepartment of Hepatopancreatobiliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaDepartment of Hepatopancreatobiliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaDepartment of Hepatopancreatobiliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaDepartment of Hepatopancreatobiliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaDepartment of Hepatopancreatobiliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaDepartment of Hepatopancreatobiliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, ChinaObjective Hepatitis B virus (HBV) remains an important risk factor for hepatocellular carcinoma (HCC), and inflammation plays an essential role in tumor development. This study aimed to investigate the impact of inflammatory markers in the postoperative outcomes of patients with HBV-related HCC, providing valuable prognostic indicators after hepatectomy.Methods We retrospectively analyzed 222 patients with HBV-related HCC after surgical resection. The ROC curve was used to calculate biomarker cutoff values. The Kaplan–Meier method was used to estimate overall survival (OS) and recurrence-free survival (RFS), and univariate and multivariate analyses were used to identify the prognostic factors.Results The Kaplan–Meier analysis revealed that patients with high albumin-bilirubin (ALBI) score, aspartate aminotransferase to platelet ratio index (APRI), and monocyte to lymphocyte ratio (MLR) had worse OS, while those with high ALBI score and MLR had shorter RFS. Multivariate Cox regression analysis identified alpha-fetoprotein >400 ng/mL (hazard ratio [HR]: 2.447, 95% confidence interval [CI]: 1.273–4.706, p = 0.007), alanine aminotransferase (HR: 0.377, 95% CI: 0.171–0.834, p = 0.016), platelet to lymphocyte ratio (HR: 0.385, 95% CI: 0.196–0.755, p = 0.006), systemic inflammatory response index (HR: 1.844, 95% CI: 1.049–3.239, p = 0.033), ALBI score (HR: 1.808, 95% CI: 1.020–3.203, p = 0.043), APRI score (HR: 3.193, 95% CI: 1.662–6.137, p < 0.001), tumor diameter (HR: 1.083, 95% CI: 1.012–1.160, p = 0.022), and portal vein tumor thrombosis (PVTT) (HR: 6.083, 95% CI: 2.774–13.338, p < 0.0001) as independent predictors for OS. MLR (HR: 2.285, 95% CI: 1.290–4.048, p = 0.005) and PVTT (HR: 2.672, 95% CI: 1.280–5.579, p = 0.009) were confirmed as significant prognostic markers of RFS in patients with HBV-related HCC.Conclusions ALBI score, APRI, and MLR are effective prognostic predictors in patients with HBV-related HCC after curative resection. Close monitoring and adjuvant therapies should be considered for high-risk patients.https://www.tandfonline.com/doi/10.1080/08941939.2025.2475020Hepatocellular carcinomainflammatory markershepatitis B virussurvivalrecurrence |
| spellingShingle | Tao Zhou Jiongze Fang Jing Huang Xi Yu Yuying Shan Shengdong Wu Shuqi Mao Caide Lu Prognostic Value of Inflammatory Markers in HBV-Related HCC After Hepatectomy Based on a Clinical Database Journal of Investigative Surgery Hepatocellular carcinoma inflammatory markers hepatitis B virus survival recurrence |
| title | Prognostic Value of Inflammatory Markers in HBV-Related HCC After Hepatectomy Based on a Clinical Database |
| title_full | Prognostic Value of Inflammatory Markers in HBV-Related HCC After Hepatectomy Based on a Clinical Database |
| title_fullStr | Prognostic Value of Inflammatory Markers in HBV-Related HCC After Hepatectomy Based on a Clinical Database |
| title_full_unstemmed | Prognostic Value of Inflammatory Markers in HBV-Related HCC After Hepatectomy Based on a Clinical Database |
| title_short | Prognostic Value of Inflammatory Markers in HBV-Related HCC After Hepatectomy Based on a Clinical Database |
| title_sort | prognostic value of inflammatory markers in hbv related hcc after hepatectomy based on a clinical database |
| topic | Hepatocellular carcinoma inflammatory markers hepatitis B virus survival recurrence |
| url | https://www.tandfonline.com/doi/10.1080/08941939.2025.2475020 |
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