Mandibular metastasis of invasive ductal carcinoma of the breast: a case report
Abstract Background Metastasis of breast carcinoma to the oral cavity is an uncommon event, and mandibular involvement is even rarer. This case is notable owing to the delayed occurrence of mandibular metastasis 6 years after the primary diagnosis, highlighting its aggressive behavior, which resulte...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-025-05499-2 |
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| author | Faraz SeyedForootan Nazanin Mahdavi Maryam Koopaie |
| author_facet | Faraz SeyedForootan Nazanin Mahdavi Maryam Koopaie |
| author_sort | Faraz SeyedForootan |
| collection | DOAJ |
| description | Abstract Background Metastasis of breast carcinoma to the oral cavity is an uncommon event, and mandibular involvement is even rarer. This case is notable owing to the delayed occurrence of mandibular metastasis 6 years after the primary diagnosis, highlighting its aggressive behavior, which resulted in a pathological mandibular fracture. Reporting such rare presentations can aid clinicians in identifying atypical metastatic patterns in breast cancer survivors. Case presentation A 45 year-old Persian female with a history of invasive ductal breast carcinoma, diagnosed initially and treated 6 years earlier, presented with facial swelling and pain in the left lower jaw. She had been receiving bisphosphonate therapy for bone metastases. Clinical and radiographic evaluations revealed a radiolucent mandibular lesion with cortical bone perforation. Histopathological and immunohistochemical analyses confirmed metastasis from the primary breast cancer. Despite subsequent radiotherapy and chemotherapy, the lesion progressed, resulting in a pathological mandibular fracture and further metastases to the lungs and liver. Conclusion This case underscores the importance of considering metastatic disease in diagnosing oral lesions in patients with a history of malignancy. Early recognition of atypical presentations such as mandibular metastasis may facilitate timely intervention, although prognosis remains poor in such advanced stages. |
| format | Article |
| id | doaj-art-1f4105088dc742219ccb8a98331e2be9 |
| institution | Kabale University |
| issn | 1752-1947 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj-art-1f4105088dc742219ccb8a98331e2be92025-08-24T11:31:42ZengBMCJournal of Medical Case Reports1752-19472025-08-011911710.1186/s13256-025-05499-2Mandibular metastasis of invasive ductal carcinoma of the breast: a case reportFaraz SeyedForootan0Nazanin Mahdavi1Maryam Koopaie2School of Dentistry, Tehran University of Medical SciencesDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical SciencesDepartment of Oral Medicine, School of Dentistry, Tehran University of Medical SciencesAbstract Background Metastasis of breast carcinoma to the oral cavity is an uncommon event, and mandibular involvement is even rarer. This case is notable owing to the delayed occurrence of mandibular metastasis 6 years after the primary diagnosis, highlighting its aggressive behavior, which resulted in a pathological mandibular fracture. Reporting such rare presentations can aid clinicians in identifying atypical metastatic patterns in breast cancer survivors. Case presentation A 45 year-old Persian female with a history of invasive ductal breast carcinoma, diagnosed initially and treated 6 years earlier, presented with facial swelling and pain in the left lower jaw. She had been receiving bisphosphonate therapy for bone metastases. Clinical and radiographic evaluations revealed a radiolucent mandibular lesion with cortical bone perforation. Histopathological and immunohistochemical analyses confirmed metastasis from the primary breast cancer. Despite subsequent radiotherapy and chemotherapy, the lesion progressed, resulting in a pathological mandibular fracture and further metastases to the lungs and liver. Conclusion This case underscores the importance of considering metastatic disease in diagnosing oral lesions in patients with a history of malignancy. Early recognition of atypical presentations such as mandibular metastasis may facilitate timely intervention, although prognosis remains poor in such advanced stages.https://doi.org/10.1186/s13256-025-05499-2Breast cancerMandibular metastasisOral cavityInvasive ductal carcinomaMetastatic tumorsBone metastasis |
| spellingShingle | Faraz SeyedForootan Nazanin Mahdavi Maryam Koopaie Mandibular metastasis of invasive ductal carcinoma of the breast: a case report Journal of Medical Case Reports Breast cancer Mandibular metastasis Oral cavity Invasive ductal carcinoma Metastatic tumors Bone metastasis |
| title | Mandibular metastasis of invasive ductal carcinoma of the breast: a case report |
| title_full | Mandibular metastasis of invasive ductal carcinoma of the breast: a case report |
| title_fullStr | Mandibular metastasis of invasive ductal carcinoma of the breast: a case report |
| title_full_unstemmed | Mandibular metastasis of invasive ductal carcinoma of the breast: a case report |
| title_short | Mandibular metastasis of invasive ductal carcinoma of the breast: a case report |
| title_sort | mandibular metastasis of invasive ductal carcinoma of the breast a case report |
| topic | Breast cancer Mandibular metastasis Oral cavity Invasive ductal carcinoma Metastatic tumors Bone metastasis |
| url | https://doi.org/10.1186/s13256-025-05499-2 |
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